The histamine effect on leukocytal generation of reactive oxygen species during bronchial asthma of various forms and the severity degree

Abstract

The histamine effect on leukocytal generation of reactive oxygen species (LGROS) with Si0₂ stimulation was investigated by the luminol dependent chemiluminescence (ChL) method in 65 patients with bronchial asthma and in 19 donors. Histamine decreased LGROS in most of the donors, while in most of patients it increased LGROS. The reaction increase degree and the reaction frequency depended on form, stage, severity degree and duration of the disease. It was concluded that histamine can be included into the bronchial asthma pathogenesis not only by the way of direct bronchoconstriction stimulation, but with of the increase of LGROS. The supposition was made about possibility of the certain reaction use as an additional test for estimating the exacerbation degree and prognosis of the bronchial asthma course.