Immunological and coagulological parallels in patients with chronic bronchitis

Abstract

The character and the degree of the functional interaction between basal chains of immunity and hemocoagulation during disease evolution were investigated in 114 patients with chronic bronchitis (CB) including 24 ones with nonobstructive and 18 with asthmatic forms of the disease. 36 healthy volunteers were as a control group.

During three days after hospitalization, the studies were carried out. The cell dependant immunity, circulating immune complexes, and the total hemolytic activity of complement were determined. The phagocytai activity of leukocytes was evaluated with the standard technique. The hemostasis state was estimated with the kaolin-kefalin time count and autocoagulogramm parameters.

The hemocoaulation analysis revealed the presence of chronic intravessel blood coagulation (IBC) which was testified about by hypercoagulation, moderate pro- and anticoagulants consumption, and the shift dynamics of hemostasis during the CB progressing. Coupling with that, the immunological reactivity is depressed, that defines the evolution rate of the disease.