The effect of saltos single use on histamine induced bronchoconstriction in patients with bronchial asthma
Abstract
The saltos effect on bronchial hyperresponsiveness was studied in 10 patients with bronchial asthma (4 females and 6 males), aged 20 to 59 years. The bronchial hyperresponsiveness was evaluated with bronchial challenge with histamine by the continuous normal breath method (2 minutes of aerosol inhalation) on baseline level and 3, 6, and 9 hours after medication (6 mg of the drug). FEV1 changes and provocational histamine concentration, that provided 20% of FEV1 decrease (PD20) were measured. After 3 hours, the FEV1 increase (in 5.1±1.9%, /К0.05) was noted. After 6 and 9 hours the significant FEV1 increase was not noted. After 3, 6, and 9 hours from saltos medication, the significant histamine PD 20 increase in 1.1±0.2 of dual concentration (DC), p<0.005, in 0.8±0.2 of DC, /К0.01, and in 0.8+0.2 of DC respectively was noted. The obtained data allow to consider that in single use saltos have not only the prolonged broncholitic effect, but protective action on bronchial hyperresponsiveness.
About the Authors
A. V. Cherniack
НИИ пульмонологии М3 и МП РФ
Russian Federation
Russian Federation
T. L. Pashkova
НИИ пульмонологии М3 и МП РФ
Russian Federation
Russian Federation
T. N. Bilichenko
НИИ пульмонологии М3 и МП РФ
Russian Federation
Russian Federation
A. S. Sokolov
НИИ пульмонологии М3 и МП РФ
Russian Federation
Russian Federation
A. G. Chuchalin
НИИ пульмонологии М3 и МП РФ
Russian Federation
Russian Federation
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Review
For citations:
Cherniack A.V., Pashkova T.L., Bilichenko T.N., Sokolov A.S., Chuchalin A.G. The effect of saltos single use on histamine induced bronchoconstriction in patients with bronchial asthma. PULMONOLOGIYA. 1995;(3):27-31. (In Russ.)
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