Effects of troventol on free radical status and bronchial resistance
Abstract
The effects of Russian antimuscarinic agent troventol on bronchial resistance and free radical generation in blood and bronchoalveolar lavage (BAL) were investigated in patients with chronic obstructive pulmonary disease (CO PD) and bronchial asthma (BA).
Improvement in pulmonary function tests with enhancement of airway conductance in large and middle bronchi was found in COPD patients after treatment with troventol, but in BA patients there was a less effect on airway resistance and it was more noticeable in small bronchi.
Inhaled troventol in COPD patient led to reduction of reactive oxygen species generation by phagocytes in blood and BAL. Absence of inhibition of peroxide lipid oxydation (PLO) may be explained by residual phenomenon of «respiratory burst». Monotherapy with troventol in BA patients unlike of COPD patients led to PLO reduction only in BAL.
The level of serum calcium changed nonsignificantly in observed groups after treatment.
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Review
For citations:
Yahgmurov B.H. Effects of troventol on free radical status and bronchial resistance. PULMONOLOGIYA. 1996;(4):57-59. (In Russ.)
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