Eosinophils and their morphological and functional properties in bronchial asthma
Abstract
Blood and sputum eosinophil counts, levels of eosinophil cationic protein (ECP), serum IgE, forced expiratory volume in one second (FEV1), morphometrical parameters of eosinophils were assessed in 20 consecutive patients with acute exacerbation of moderate atopic bronchial asthm a characterized by initial blood and sputum eosinophilia. Before treatment blood eosinophil count ranged from 4.1 to 20.2x108 cell/1; sputum eosinophil count – from 18 to 61% (60% of all sputum eosinophils were degranulated), the mean value of ECP concentration was 45.2 + 11.6 mkg/1; IgE level was 593.5 ± 68.2 mU/ml and FEV1 – 65.4 ± 4.5% respectively. Morphometrical assessment revealed increased main parameters of eosinophils co pared with that ones of healthy individuals. During exarcebation of asthm a there was noted a strong correlation between eosinophil counts in blood and sputum (r=0.89; p<0.05), and also between levels of ECP and IgE (r= 0.70; p< 0.05). After treatment the improvement in general condition was accompanied by trustwothy fall in blood eosinophils count (more than 2,3 fold), in sputum eosinophil count (more than 2,2 fold); ECP level – by 36%; IgE level – by 28% and increase in of FEV1 – by 28%, and also decrease in morphometrical dimensions of eosinophils was revealed. There were relaible correlations between fall in ECP concentration and FEV1 increament, between aforementioned changes in blood eosinophil count and changes of FEV1 and ECP. These findings demonstrate the signifficance of blood and sputum eosinophilia in the cause of bronchial asthma and association between inflammatory changes in airways and clinical couse of bronchial asthma during treatment.
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For citations:
Anaev E.H. Eosinophils and their morphological and functional properties in bronchial asthma. PULMONOLOGIYA. 1996;(3):54-57. (In Russ.)
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