Homeostatic indices in pulmonary sarcoidosis

Abstract

In 69 patients with pulmonary sarcoidosis the following homeostatic indices were studied before and after treatment: parameters of immunological tests, peroxide lipid oxidation, enzyme antioxidant defence, hormonal profile. The considerable disorders of all chains in systemic immunity were revealed: attenuation of T-lymphocytes with their subpopulation discrepancy, decreasing levels of IgA, M, G and increasing level of fibronectin. Significant changes in bronchopulmonary lavage fluid were found: decrease of alveolar macrophages, increase in lymphocytes, neutrophils, fibronectin and secretory IgA. The intensification of peroxide lipid oxidation was accompained by reduced antioxidant defense and pronounced hormonal disbalans was also marked. The criteria for differential diagnosis of pulmonary sarcoidosis and tuberculosis were elaborated.