Influence of maxaquin on ultrastructure of mycobacterium tuberculosis
Abstract
The influence of Maxaquin (Lomefloxacin) on the structure of mycobacterium tuberculosis strain H37Rv was studied in vitro. At 0.5 mkg/ml concentration of maxaquin during 24 hours the disorders in lipid capsule covering the microorganisms and in intercellular cooperation were marked. At 10 mkg/ml concentration of maxaquin there were profound destructive alterations in colony architecture and cell ultrastructure. Under maxaquin influence there were destruction of cell membrane, désorganisation of cytoplasm and organoids of mycobacteruims and lost of their viability.
About the Authors
G. N. Mozhokina
Российский научно-исследовательский институт фтизиопульмонологии М3 РФ
Russian Federation
Russian Federation
N. S. Smirnova
Российский научно-исследовательский институт фтизиопульмонологии М3 РФ
Russian Federation
Russian Federation
T. N. Levchenko
Российский научно-исследовательский институт фтизиопульмонологии М3 РФ
Russian Federation
Russian Federation
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Review
For citations:
Mozhokina G.N., Smirnova N.S., Levchenko T.N. Influence of maxaquin on ultrastructure of mycobacterium tuberculosis. PULMONOLOGIYA. 1997;(2):38-42. (In Russ.)
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