About some therapeutic effects of intal

Abstract

93 patients suffering from bronchial asthma and taking intal were examined. The phenomenon of decreasing the need in glucocorticosteroid hormones injected in vitro was studied. In order to estimate the tissue sensitivity to the giucocorticosteroid hormones the cortisole-absorption of lymphocytes (CAL) and erythrocytes (CAE) was determined together with its modification for preincubation with 0.2 ml of 5x10^-4 g/l intal solution. For two-week intai course the number of asphyxia and cough attacks reduced. We managed to reduce the dose of injected glucocorticosteroid hormones for 62.5 percent of patients. However the level of 11-OKS blood plasma did not changed. The CAL and CAE indices for patients suffering from bronchial asthma was authentically lower than those for healthy people. After preincubation of blood cells with intal solution the CAL increased for sick patients, but for healthy peopie this phenomenon was not observed. The maximum CAL and CAE increment was observed for patients suffering from bronchial asthma with the main infection-dependent disease, on the background of steroid therapy (mainly by inhalation) and for initially reduced CAL indices. On the contrary for the patients with the normal sensitivity to cortisole the preincubation of cells with intal did not significantly influenced on CAL. Thus the in vitro preincubation of blood cells with intal promotes the increase of blood cells sensitivity to cortisole. Bronchial asthma patients with lymphocyte and erythrocyte low sensitivity to cortisole should be given chromoglycate sodium preparations in order to decrease tissue cortisole resistance level.