Influence of melatonin on functional thrombocytes activity in aspirin-induced asthma patients
Abstract
Main metabolite of melatonin (MT) — 6-sulfatoxymelatonin (6-SOMT) urine contence and the influence of different melatonin doses in vitro on ADF-induced thrombocytes (T) aggregation were studied in 17 aspirin-induced asthmatic patients (AIA), 17 non-aspirin-induced asthmatic patients (NAA) and 16 healthy subjects. It was found that daytime urine 6-SOMT excretion in aspirin-induced asthmatics was lower that evidances reduced melatonin synthesis. Melatonin level in human organism effects on ADF-induced thrombocytes aggregation and on change of its parameters in consequent addition of melatonin in vitro. Aspirin-induced asthmatics have increased intensity and rate of the first aggregation phaze during incubation of enriched by T blood plasma with MT in dose 0.01 pg/ml of plasma in difference from non-asthmatics and healthy subjects that is connected with openning of receptor-operated calcium canals and/or calcium’s comming out of intracellular depot. The obtained results evidance the reception’s disorder of melatonin and its metabolite — N-acetyl-5-metoxykinurenamine, which chemically is like acetylsalicylic acid — in aspirin-induced asthma.lt possibly defines aspirin intolerance in aspirin-induced asthma patients.
About the Authors
G. B. Fedoseev
Кафедра госпитальной терапии и патологической физиологии Санкт-Петербургского государственного медицинского университета им.акад. И.П.Павлова
Russian Federation
Russian Federation
N. N. Petrischev
Кафедра госпитальной терапии и патологической физиологии Санкт-Петербургского государственного медицинского университета им.акад. И.П.Павлова
Russian Federation
Russian Federation
E. V. Evsiukova
Кафедра госпитальной терапии и патологической физиологии Санкт-Петербургского государственного медицинского университета им.акад. И.П.Павлова
Russian Federation
Russian Federation
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Review
For citations:
Fedoseev G.B., Petrischev N.N., Evsiukova E.V. Influence of melatonin on functional thrombocytes activity in aspirin-induced asthma patients. PULMONOLOGIYA. 1998;(3):40-44. (In Russ.)
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