Efficacy of combined therapy with fluticasone propionate and salmeterol in asthmatic patients
Abstract
Current study present results of comnblned treatment with fluticasone propionate and salmeterol in 52 patients with moderate persistent asthma (11 male, 41 female), who received inhaled steroids for more than 3 month before study and/or in combination with different brochodilators.
Efficacy of the treatment (fluticasone — 250 meg, salmeterol — 50 meg) during 9 weeks was evaluated by clinical observation, peak flow and flow-volume measurement with reversibility response to pronchodilators and daily needs to short acting β2-agonists.
Obtained results demonstrated that administration of ccombined therapy with fluticasone and salmeterol the optimal way of treatment of patients according to efficacy and security. This treatment provide stabile and long-term effect on bronchial contuctance and daily variability and support its efficacy during whole treatment period. Combined administration of fluticasone and salmeterol doesn’t have serious systemic and cardiotoxic side effects.
About the Authors
Z. Aisanov
НИИ пульмонологии М3 РФ
Russian Federation
Russian Federation
O. Stulova
НИИ пульмонологии М3 РФ
Russian Federation
Russian Federation
E. Kalmanova
НИИ пульмонологии М3 РФ
Russian Federation
Russian Federation
M. Beda
НИИ пульмонологии М3 РФ
Russian Federation
Russian Federation
O. Mednikova
НИИ пульмонологии М3 РФ
Russian Federation
Russian Federation
A. Pereseckiy
НИИ пульмонологии М3 РФ
Russian Federation
Russian Federation
A. Chuchalin
НИИ пульмонологии М3 РФ
Russian Federation
Russian Federation
References
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Review
For citations:
Aisanov Z., Stulova O., Kalmanova E., Beda M., Mednikova O., Pereseckiy A., Chuchalin A. Efficacy of combined therapy with fluticasone propionate and salmeterol in asthmatic patients. PULMONOLOGIYA. 1998;(3):14-18. (In Russ.)
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