Changes in alveolar macrophage functional phenotype under an influence of age and genetic susceptibility as risk factors for chronic obstructive pulmonary disease
https://doi.org/10.18093/0869-0189-2013-0-6-732-738
Abstract
Summary. A definitive role of tobacco smoking as a risk factor for development of chronic obstructive pulmonary diseases (COPD) is of no doubt today. We performed in vivo experimental modeling of COPD in mice of different genetic strains (С57 and Balb/c). We studied phenotypes of main cells of the innate immunity that are alveolar macrophages, and revealed genetic and age susceptibility to COPD in experimental animals. We showed that 1) there is a certain genetic susceptibility to hazardous exposition of tobacco smoke, probably, associated with proinflammatory М1 macrophage phenotype; 2) aging promotes transformation of macrophage phenotypes towards antiinflammatory М2 which is more expressed in mice macro-phages with baseline genetically determined М1 phenotype (mice strain С57), and 3) long-time exposition to tobacco smoke enhances age-dependent macrophage transformation aside М2 phenotype, that is also more expressed in mice macrophages with genetically determined М1 phenotype (С57).
About the Authors
S. V. Lyamina
ГБОУ ВПО "Московский государственный медико-стоматологический университет им. А.И.Евдокимова" Минздрава России
Russian Federation
Russian Federation
Sh. L. Shimshelashvili
ГБОУ ВПО "Московский государственный медико-стоматологический университет им. А.И.Евдокимова" Минздрава России; Институт стоматологии новых технологий
Russian Federation
Russian Federation
T. Yu. Vedenikin
ГБОУ ВПО "Московский государственный медико-стоматологический университет им. А.И.Евдокимова" Минздрава России
Russian Federation
Russian Federation
E. V. Malysheva
ГБОУ ВПО "Московский государственный медико-стоматологический университет им. А.И.Евдокимова" Минздрава России
Russian Federation
Russian Federation
N. P. Larionov
ФГБОУ ВПО "Владимирский государственный университет им. Александра Григорьевича и Николая Григорьевича Столетовых"
Russian Federation
Russian Federation
I. Yu. Malyshev
ГБОУ ВПО "Московский государственный медико-стоматологический университет им. А.И.Евдокимова" Минздрава России; УРАМН НИИ общей патологии и патофизиологии РАМН
Russian Federation
Russian Federation
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Review
For citations:
Lyamina S.V., Shimshelashvili Sh.L., Vedenikin T.Yu., Malysheva E.V., Larionov N.P., Malyshev I.Yu. Changes in alveolar macrophage functional phenotype under an influence of age and genetic susceptibility as risk factors for chronic obstructive pulmonary disease. PULMONOLOGIYA. 2013;(6):33-37. (In Russ.) https://doi.org/10.18093/0869-0189-2013-0-6-732-738
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