Comparative efficacy of different preventing medication modes in post-exercise bronchoconstriction in children: multi-center randomized study results
I. V. Smolenov,
L. M. Ogorodova,
S. A. Stakhanova,
Yu. A. Petrovskaya,
N. A. Ivanova,
N. G. Mashukova,
V. R. Lipina,
N. A. Smirnov,
Yu. Yu. Zima
- Р Р‡.МессенРТвЂВВВВВВВВжер
- РћРТвЂВВВВВВВВнокласснРСвЂВВВВВВВВРєРСвЂВВВВВВВВ
- LiveJournal
- Telegram
- ВКонтакте
- РЎРєРѕРїРСвЂВВВВВВВВровать ссылку
Full Text:
Abstract
The article demonstrates results of multi-center randomized placebo-controlled study of efficacy of 4 drug modes of post-exercise bronchoconstriction prevention in asthmatic children who received long-term therapy with inhaled corticosteriods. The combination of fluticazone propionate and salmeterol (Seretid 50/100) was found to be beneficial and reasonable as the first-line therapy. An increase of the inhaled corticosteroid’s dose in asthmatic children with post-exercise bronchoconstriction is reasonable if its combination with the long-acting β2-agonist does not permit to achieve a sufficient bronchoprotective effect.
About the Authors
I. V. Smolenov
Государственная медицинская академия
Russian Federation
Russian Federation
L. M. Ogorodova
Сибирский государственный медицинский университет
Russian Federation
Russian Federation
S. A. Stakhanova
Государственная медицинская академия
Russian Federation
Russian Federation
Yu. A. Petrovskaya
Сибирский государственный медицинский университет
Russian Federation
Russian Federation
N. A. Ivanova
Военно-медицинская академия
Russian Federation
Russian Federation
N. G. Mashukova
Ангарский астма-центр
Russian Federation
Russian Federation
V. R. Lipina
Городская детская больница № 9
Russian Federation
Russian Federation
N. A. Smirnov
Государственная медицинская академия
Russian Federation
Russian Federation
Yu. Yu. Zima
Государственная медицинская академия
Russian Federation
Russian Federation
References
1. Standartizatsiya legochnykh funktsional'nykh testov. Doklad rabochei gruppy "Standartizatsiya testov legochnoi funktsii". Ofitsial'nyi otchet "Evropeiskogo respiratornogo obshchestva". M .: Pul'monologiya; 1993.
2. Chuchalin A.G., S kolov A.C., Pashkova T.L. i dr. Opyt primeneniya prolongirovannogo r2.simpatomimetika sal'meterola u bol'nykh bronkhial'noi astmoi. Pul'monologiya 1996; 2: 79-83.
3. Shmushkovich B.I. Klinicheskaya effektivnost' i mekhanizmy protivovospalitel'nogo deistviya glyukokortikoidnykh gormonov v lechenii bol'nykh bronkhial'noi astmoi. V kn.: Ch u chalin A.G. (red.) Bronkhial'naya astma. M .; 1997; T.2: 224-253.
4. Bleecker E.R., Welch M.J., Weinstein S.F. et al. Low-dose inhaled fluticasone propionate versus oral zafirlukast in the treatment of persistent asthma. J. Allergy Clin. Immunol. 2000; 105 (6, pt 1): 1123-1129.
5. Juniper E.F., Guyatt G.H., Willan A., Griffith L.E . Determining a minimal important change in a disease-specific quality of life questionnaire. J. Clin. Epidemiol. 1994; 47 (1): 81-87.
6. Kelly K.D., Spooner S.I., Rowe B.H. Nedocromil sodium vs cromoglycate for preventing exercise induced bronchoconstriction in asthma. (Cochrane review). In: The Cochrane library. Oxford: Update Software; 2000; issue 3.
7. Pdersen S. Safety aspects of corticosteroids in children. Eur. Respir. Rev. 1994; 4 (17): 33-43.
8. Pollard S.J., Spector S.L., Yancey S.W . et al. Salmeterol versus theophylline in the treatm ent of asthma. Ann. Allergy Asthma Immunol. 1997; 78 (5): 457-464.
9. Rufin P., Scheinmann P., De-Blic J. Exercise-induced asthma. Diagnosis, prophylaxis and treatment. BioDrugs 1997; 8 (1 ): 6-15.
10. Taylor W.R., Newacheck P.W. Impact of childhood asthma on health. Pediatrics 1992; 90: 657-662.
Review
For citations:
Smolenov I.V., Ogorodova L.M., Stakhanova S.A., Petrovskaya Yu.A., Ivanova N.A., Mashukova N.G., Lipina V.R., Smirnov N.A., Zima Yu.Yu. Comparative efficacy of different preventing medication modes in post-exercise bronchoconstriction in children: multi-center randomized study results. PULMONOLOGIYA. 2002;(2):50-57. (In Russ.)
Views:
166
ISSN 0869-0189 (Print)
ISSN 2541-9617 (Online)
ISSN 2541-9617 (Online)
Email this article 