Foradil and its place in bronchial asthma therapy
Abstract
Today formoterol fumarat (Foradil) is the most well-known long-acting ß2-agnist worldwide. This review discusses characteristic features of the active substance, its comparison with other ß2-agonists and its delivery as well. Specific pharmacologic characteristics of the drug are viewed to determine its place in the modern spectrum of antiasthmatic and bronchodilating medications. Study results demonstrating unique pharmacologic properties of formoterol are given: high effectiveness together with high ß2-selectivity; high intrinsic activity; rapid starting the action; the effect duration. An intermediate lipophylity hypothesis is reported to explain the unique combination of formoterol pharmacologic properties compared with clear lipophylic agents, such as salmeterol.
Recent data evidence that formotero! (Foradil) is the most optimal and universal (in terms of the action rate and duration) bronchodilating drug which can be used as symptomatic means in mild bronchial asthma patients and as the first-line therapy for asthma control and nighttime attacks prevention, and as a preventing drug for bronchospasm development caused by different triggers. A joined application of the formoterol and inhaled medications is proved to be the most effective combination and is recommended by the majority of modern guidelines for severe asthma management.
About the Authors
E. N. Kalmanova
НИИ пульмонологии М3 РФ
Russian Federation
Russian Federation
Z. R. Aisanov
НИИ пульмонологии М3 РФ
Russian Federation
Russian Federation
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Kalmanova E.N., Aisanov Z.R. Foradil and its place in bronchial asthma therapy. PULMONOLOGIYA. 2001;(1):65-72. (In Russ.)
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