Форадил и его место в терапии бронхиальной астмы
Аннотация
Формотерола фумарат в форме Форадила является самым распространенным и хорошо изученным пролонгированным ß2-агонистом, представленным сегодня на мировом фармацевтическом рынке. В настоящем обзоре обсуждены особенности как самого активного вещества, так и его сравнение с другими ß2-агонистами, а также сравнительный анализ средств доставки. Для того, чтобы определить место препарата в современном спектре антиастматических и бронходилатационных средств, рассмотрены его специфические характеристики как препарата, являющегося представителем своего класса. Приведены данные исследований, демонстрирующих уникальное сочетание фармакологических свойств формотерола: высокая эффективность в сочетании с высокой ß2-селективностью; высокая внутренняя активность; быстрое начало действия; продолжительность эффекта. Изложена гипотеза промежуточной липофильности, объясняющая уникальность сочетания фармакологических свойств формотерола по сравнению с чисто липофильными агентами, такими как сальметерол.
Имеющиеся на сегодняшний день данные свидетельствуют о том, что формотерол (Форадил) является наиболее оптимальным и универсальным (с точки зрения быстроты и продолжительности действия) бронхорасширяющим препаратом, который может применяться и как симптоматическое средство у больных бронхиальной астмой легкого течения, и как препарат первой линии для контроля течения заболевания и предотвращения ночных приступов бронхиальной астмы, а также в качестве профилактического средства для предотвращения бронхоспазма, вызванного различными триггерами. Сочетанное применение препарата с ингаляционными средствами признано наиболее эффективной комбинацией в большинстве современных руководств по лечению тяжелой бронхиальной астмы.
Об авторах
Е. Н. Калманова
НИИ пульмонологии М3 РФ
Россия
Россия
З. Р. Айсаиов
НИИ пульмонологии М3 РФ
Россия
Россия
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Рецензия
Для цитирования:
Калманова Е.Н., Айсаиов З.Р. Форадил и его место в терапии бронхиальной астмы. Пульмонология. 2001;(1):65-72.
For citation:
Kalmanova E.N., Aisanov Z.R. Foradil and its place in bronchial asthma therapy. PULMONOLOGIYA. 2001;(1):65-72. (In Russ.)
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