A ground for differentiated application of non-specific pathogenic medications in a complex therapy of lung tuberculosis patients

Abstract

A significance of the status of macroorganism adaptive systems in the evaluation of lung tuberculosis peculiarities was confirmed by the investigation of lipid peroxidation process (LP) in this disease. Results of observation of 46 patients revealed a precise relationship between a therapy efficacy and LP activity. This fact allowed to consider MDA (that is a LP final product) level as a test for prognosis of a tuberculosis course and determination of the persons needing the poor tuberculosis course to be corrected. The results were confirmed by an assessment of gene products expression regarding the region responsible to anti-tuberculosis immunity itself and its intensity. Based on this information the immunological reactivity of tuberculosis patients was studied to estimate a prior correcting therapy. The complex treatment of 56 tuberculosis patients involved antioxidants, new immunocorrector Polyoxidony itself and its combination with lidase. The clinical and laboratory correlation found a clear differentiation of the relationship between those drugs’ clinical effectiveness and immune system restoration. This fact substantiated recommendations for the drugs’ differentiated application depending on peculiarities of lung tissue reaction and tuberculosis form and severity.