Diurnal variability of arterial blood pressure and peak expiratory flow rate in patients with bronchial asthma and concurrent essential hypertension
Abstract
In this study we investigated diurnal variability of arterial blood pressure (BP) and peak expiratory flow rate (PEF) in 61 asthmatic patients (the mean age 51.6±1.3 yrs) and 13 healthy controls. Sixteen asthmatics had the essential hypertension (EH), stage I, 15 had the stage II, 20 patients had normal BP. All patients were treated according to recommendations of Global Initiative for Asthma (GINA, 1993). Hypotensive drugs were not used.
We observed-a correlation between BP diurnal values and PEF in some asthmatics, especially in patients with EH, stage I; an improvement in lung function parameters was accompanied by a decrease in BP diurnal values. A relative variability of BP diurnal values was higher in asthma patients with concurrent EH, especially of stage I. The treatment of bronchial asthma exacerbation led to an improvement in lung function parameters and significantly decreased PEF diurnal variability (p<0.05), but did not change the BP diurnal variability.
About the Authors
A. G. Kozyrev
НИИ пульмонологии СПбГМУ им. акад. И.П. Павлова
Russian Federation
Russian Federation
V. F. Zhdanov
НИИ пульмонологии СПбГМУ им. акад. И.П. Павлова
Russian Federation
Russian Federation
References
1. Горбунов В.М. Значение исследования различных видов вариабельности артериального давления у больных с артериальной гипертензией. Кардиология 1997; 37 (1): 66-69.
2. Жданов В.Ф. Системная артериальная гипертензия у больных бронхиальной астмой: Дис. ... д-ра мед. наук. СПб; 1993.
3. Клочков В.А. Использование анализа суточного профиля артериального давления для диагностики и лечения артериальной гипертензии. Кардиология 1999; 39 (4): 26-29.
4. Соса А., Sobrino J., Soler J. et al. Trough-to-peak ratio and circadian blood pressure profile after treatment with once-daily extended-release diltiazem, 240 mg, in patients with mild-to-moderate essential hypertension. J. Cardiovasc. Pharmacol. 1997; 29 (3): 316-322
5. Gosse P., Jullien E., Reynaud P., Dallocchio M. Circadian rhythm of blood pressure. Importance of the severity and not the cause of arterial hypertension. Arch. Mal. Coeur. Vaiss. 1988; 81 (Spec. No): 247-250.
6. Kawecka-Jaszcz К. Diagnosis of early hypertension with continuous ambulatory blood pressure monitoring. Pol. Tyg. Lek. 1994; 49 (10-11): 257-260.
7. Tsunoda K., Abe K., Hagino T. et al. Hypotensive effect of losartan, a nonpeptide angiotensine II receptor antagonist, in essential hypertension. Am. J. Hypertens. 1993; 6 (1): 28-32.
Review
For citations:
Kozyrev A.G., Zhdanov V.F. Diurnal variability of arterial blood pressure and peak expiratory flow rate in patients with bronchial asthma and concurrent essential hypertension. PULMONOLOGIYA. 2003;(2):52-56. (In Russ.)
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