Effect of long-term tobacco smoking on lipid peroxidation and immune system in chronic bronchitis patients
Abstract
Tobacco smoking is known to play a major role in the pathogenesis of chronic bronchitis (CB). The aim of this investigation was to determine an influence of long-term tobacco smoking on lipid peroxidation (LP) processes, antioxidant activity, and immune status in 122 stable CB patients. The study group Included 60 "unconditional" smokers (the smoking history was 19.0 ± 0.7 pack-years). The control group consisted of 62 nonsmokers.
It was found that tobacco smoking resulted in activation of LP processes (an Increase in malonyldlaldehyde serum level) and to formation of a new oxidant-antioxidant balance at higher level of free radical oxidation. Smoking also had an immunosuppressive effect on local immunity (decrease In secretory IgA and lysozyme levels). Thus, the data obtained confirmed the Importance of smoking cessation in the management of CB patients.
References
1. Глобальная стратегия/: диагностика, лечение и профилактика хронической обструктивной болезни легких. Доклад рабочей группы Национального Института сердца, легких и крови и Всемирной организации здравоохранения. Краткое изложение. 1998.
2. Голуб Н.И. Влияние табакокурения на иммунную и неспецифическую резистентность. Пульмонология 1992; 1: 83-86.
3. Фещенко К).И., Яшина Л.А., Горовенко Н.Г. Хронические обструктивные заболевания легких. Киев: Морион; 2001.
4. Hunninghake G.W .,Crystal R.G. Cigarette smoking and lung destruction. Accumulation of neutrophils in the lungs of cigarette smokers. Am. Rev. Respir. Dis. 1983; 128: 833-838.
5. Lapenna B.C., De Geoia S., M ezzetti A. et al. Cigarette smoke, ferritin and peroxidation. Am. J. Respir. Crit. Care Med. 1995; 151: 431-435.
6. Wright J.L., Lawson L.M., Pare P.O. et al. Morphology of peripheral airways in current smokers and ex-smokers. Am. Rev. Respir. Dis. 1983; 127: 474-477.
7. Хронические обструктивные болезни легких. Федеральная программа. М.; 1999.
8. Оценка иммунологического статуса человека: Метод, рекомендации / Петров Р.В., Лопухин Ю.М., Чередеев А.И. и др. М.; 1984.
9. Chow С.К. Cigarette smoking and oxidative damage in the lung. Ann. N. Y. Acad. Sci. 1993; 686: 289-298.
10. Toth К.М.,Berger R.E., Beehler E.M., Repine J.E. Erythrocytes from cigarette smokers contain more gluthatione and catalase and protect endothelial cells from hydrogen peroxide better than erythrocytes from nonsmokers. Am. Rev. Respir. Dis. 1993; 134: 281-284.
Review
For citations:
Syurin S.A. Effect of long-term tobacco smoking on lipid peroxidation and immune system in chronic bronchitis patients. PULMONOLOGIYA. 2004;(2):83-85. (In Russ.)
Views:
253
Email this article 