Influence of smoking on endothelial dysfunction in COPD patients
Abstract
Sixty males with COPD were examined, their average age was 47.6 ± 1.13 yrs. The mild to moderate COPD patients were included into the 1-st group and the severe COPD patients were involved in the 2-nd group. Fifty one healthy volunteers were the control group, they were divided into the 1-st control group (35 nonsmokers) and the 2-nd control group (16 active smokers without bronchial obstruction). The endothelial function was searched using the reactive hyperemia test and the nitroglycerin test. An amount of desquamated blood endotheliocytes was detected with J.HIadovec's method (1978).
The COPD patients and the active smokers of the control group had the number of circulating endothelial cells significantly more than in healthy. The COPD patients and the 2-nd control group smokers also had reliably wider brachial artery diameter and lower level of flow-dependent dilation when compared with the healthy nonsmokers. So, the COPD patients demonstrated features of endothelium lesion and disorders of vasoregulating activity of the vascular wall requiring further investugation.
About the Authors
N. A. Karoli
Саратовский государственный медицинский университет
Russian Federation
Russian Federation
A. P. Rebrov
Саратовский государственный медицинский университет
Russian Federation
Russian Federation
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Review
For citations:
Karoli N.A., Rebrov A.P. Influence of smoking on endothelial dysfunction in COPD patients. PULMONOLOGIYA. 2004;(2):70-78. (In Russ.)
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