Catecholamine lung excretion in patients with bronchial asthma and essential hypertension
Abstract
In this study the morning (9 a.m.) and evening (6 p.m.) levels of noradrenaline (NA) and dopamine (D) were investigated by spectrofluorometry in breathing condensate (B P ) from 51 asthmatic patients (mean age 51.4 ± 1.5 yrs) and 13 healthy controls. 16 asthmatics had stage I of essential hypertension (EH), 15 — stage II, 20 patients had normal blood pressure. All patients were treated according to recommendations of Global initiative for asthma (GINA), 1993. Hypotensive drugs were not used. The evening level of NA excretion after exercebation of bronchial asthma (BA) was significantly higher in astmatics with stage I of EH (10.27 ± 4.50 mkg/l), than in astmatics with stage II of EH (1.42 ± 0.58 mkg/l) and control group (0.57 ± 0.42 mkg/l), p < 0.05. Morning level of D excretion before asthma treatment in all asthmatics was significantly higher, than in control group, and after treatment — in asthmatics with stage I of EH only (0.307 ± 0.119 mkg/ml), p < 0.05.
The data obtained suggested higher catecholamine excretion in asthmatics with stage I of EH. B P investigation could give valuable information about changes in catechoamine metabolism in patients with BA and EH.
About the Authors
A. G. Kozyrev
НИИ пульмонологии Санкт-Петербургского государственного медицинского университета им. акад. И.П.Павлова
Russian Federation
Russian Federation
E. K. Dotsenko
НИИ пульмонологии Санкт-Петербургского государственного медицинского университета им. акад. И.П.Павлова
Russian Federation
Russian Federation
V. A. Goncharova
НИИ пульмонологии Санкт-Петербургского государственного медицинского университета им. акад. И.П.Павлова
Russian Federation
Russian Federation
V. F. Zhdanov
НИИ пульмонологии Санкт-Петербургского государственного медицинского университета им. акад. И.П.Павлова
Russian Federation
Russian Federation
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Review
For citations:
Kozyrev A.G., Dotsenko E.K., Goncharova V.A., Zhdanov V.F. Catecholamine lung excretion in patients with bronchial asthma and essential hypertension. PULMONOLOGIYA. 2004;(2):31-34. (In Russ.)
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