Lung cancer in radiation industry workers and residents of radionuclide-polluted territories of Russia: histological and molecular genetic features
Abstract
The aim of the study was to examine morphologic and molecular genetic features of lung cancer in patients engaged in radiation industry or living at radionuclide-polluted territories of Russia.
We performed morphologic and immunohistochemical investigations of lung cancer samples from patients engaged in radiation industry (16 cases) and patients living in radionuclide-polluted areas of Tula (8 cases) and Semipalatinsk (17 cases) regions. The immunuhistochemical analysis of lung cancer biomolecular markers (p53, bcl-2, c-myc, and ki67) and the transmission electronic microscopy with energy-dispersed analysis of dust chemical elements were performed.
We showed that lung cancer in patients exposed to low-dose radiation has some peculiarities. Fibrosis was a frequent background for peripheral lung cancer occurrence. Perivascular or peribronchial fibrosis with dust deposition was usual in these cases. Cesium presented in the dust deposits in patients from Tula region. Increased small cell lung cancer rate with low proliferative activity was typical in patients worked at the radiation industry.
About the Authors
M. V. Samsonova
НИИ пульмонологии М3 и СР РФ
Russian Federation
Russian Federation
G. Sagindikova
ММА им. И.М. Сеченова
Russian Federation
Russian Federation
A. L. Chernyaev
НИИ пульмонологии М3 и СР РФ
Russian Federation
Russian Federation
E. A. Kogan
ММА им. И.М. Сеченова
Russian Federation
Russian Federation
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Review
For citations:
Samsonova M.V., Sagindikova G., Chernyaev A.L., Kogan E.A. Lung cancer in radiation industry workers and residents of radionuclide-polluted territories of Russia: histological and molecular genetic features. PULMONOLOGIYA. 2004;(6):30-34. (In Russ.)
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