First triple therapy in one inhaler for COPD patients: treatment approach (scientific data overview)
https://doi.org/10.18093/0869-0189-2020-30-6-813-821
Abstract
Chronic obstructive pulmonary disease (COPD) is one of the leading causes of disability and mortality. The paper discusses the role of single inhaler triple therapy in COPD maintenance treatment. Trelegy Ellipta - the first fixed triple combination registered in Russia - is taken as an example. Below we deliberate on classes of components and their mechanism of action, clinical effectiveness, influence on exacerbations' risk, functional and patient-reported outcomes, safety, and mortality reduction. We also discuss the approaches for triple therapy administration to COPD patients recommended by a row of national and global guidelines.
Keywords
chronic obstructive pulmonary disease (COPD),
COPD maintenance treatment,
triple therapy,
inhaled corticosteroid,
triple combinations,
COPD exacerbations,
Trelegy Ellipta
Supporting agencies: This publication is supported by GlaxoSmithKline Trading Joint Stock Company, according to the current legislation of Russian Federation and Good Publication Practice standards
About the Authors
S. N. Avdeev
I.M.Sechenov First Moscow State Medical University (Sechenov University), Healthcare Ministry of Russia; Federal Pulmonology Research Institute, Federal Medical and Biological Agency of Russia
Russian Federation
Competing Interests: not
Russian Federation
Sergey N. Avdeev - Doctor ofMedicine, Professor, Corresponding Member of Russian Academy of Sciences, Head of Department of Pulmonology, I.M.Se-chenov First Moscow SMU, (Sechenov University); Head of Clinical Division, Federal PRI, Federal Medical and Biological Agency of Russia.
Ul. Trubetskaya 8, build. 2, Moscow, 119991; Orekhovyy bul'var 28, Moscow, 115682; tel.: (495) 708-35-76
Competing Interests: not
Z. R. Aisanov
N.J. Pirogov Federal Russian National Research Medical University, Healthcare Ministry of Russia
Russian Federation
Competing Interests: not
Russian Federation
Zaurbek R. Aisanov, Doctor of Medicine, Professor, Department of Pulmonology.
Ul. Ostrovityanova 1, Moscow, 117997; tel.: (495) 965-34-66
Competing Interests: not
A. V. Emelyanov
L.L. Mechnikov State North-West Medical University, Healthcare Ministry of Russia
Russian Federation
Competing Interests: not
Russian Federation
Aleksandr V. Emel'yanov - Doctor of Medicine, Professor, Head of Department of Pulmonology.
Ul. Kirochnaya 41, St. Petersburg, 191015, Russia; tel.: (812) 970-71-88
Competing Interests: not
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For citations:
Avdeev S.N., Aisanov Z.R., Emelyanov A.V. First triple therapy in one inhaler for COPD patients: treatment approach (scientific data overview). PULMONOLOGIYA. 2020;30(6):813-821. (In Russ.) https://doi.org/10.18093/0869-0189-2020-30-6-813-821
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