Peculiarities of bronchial asthma (BA) course depending on the phenomenon of overcoming the disease

Abstract

The object of the research was to study peculiarities of BA course with regard to a phenomenon of overcoming the disease.
Moderate asthma patients were recruited to the trial using a questionnaire of overcoming a disease (QOD); they were divided in 2 groups: with a high (the 1 st group) and a low (the 2 nd group) QOD index. Sputum eosinophil number, airway flow rate and pulmonary hemodynamics were investigated twice simultaneously in both the groups (in 6 and 10 or 12 months).
Patients with the high QOD index amounted 7.2 % of the patients examined. The 1 st group patients were characterized by stable treatment results, more stable condition under lower doses of inhaled steroids during the 6 month follow up and a reliable reduction in the pulmonary hypertension to the end of the follow up.
Thus, being included to the diagnostic algorithm the QOD index could allow distinguishing BA patients with favorable and unfavorable courses of the disease, improving the treatment strategy and reducing a probability of the pulmonary hypertension worsening.