Acute non-atopic late-onset asthma induced by respiratory infection
https://doi.org/10.18093/0869-0189-2005-0-1-53-57
Abstract
The aim of the study was to investigate features of respiratory infection inducing acute non-atopic late-onset asthma (NLA). Virologic and microbiologic examinations of brash biopsy samples of rhinopharyngeal and bronchial mucosa and bronchial lavage fluid were performed in 116 NLA patients admitted to a hospital in autumn and winter.
The leading cause of acute NLA was found to be respiratory viral infections. We noted that different clinical NLA types had different sensibility to various viruses: adenoviruses mainly caused exacerbations of aspirin-induced asthma, respiratory syncytial and influenza A viruses were prevalently determined in non-atopic asthma. Patients with posttuberculotic lesions of the lungs mostly had viral and bacterial associations. Such mixed infection resulted in more severe and prolonged exacerbations of NLA.
About the Authors
S. A. Sobchenko
Санкт-Петербургская медицинская академия последипломного образования
Russian Federation
Russian Federation
O. S. Schetchikova
Санкт-Петербургская медицинская академия последипломного образования
Russian Federation
Russian Federation
N. V. Yakovleva
Научно-исследовательский институт пульмонологии Санкт-Петербургского медицинского университета им. акад. И.П.Павлова
Russian Federation
Russian Federation
References
1. Собченко С.А. Клинические варианты поздней астмы. В кн.: Тезисы докладов 7-го Национального конгресса по болезням органов дыхания. М.: 1997. 49.
2. Brinke A. Persistent airflow limitation in adult-onset nonatopic asthma is associated with serologic evidence of Chlamydia pneumoniae infection. J. Allergy Clin. Immunol. 2001; 107 (3): 449—454.
3. Reed C. E. The natural history of asthma in adults: The problem of irreversibility. J. Allergy Clin. Immunol. 1999; 103 (18): 432—442.
4. Isaacs D., Joshi P. Respiratory infections and asthma. Med. J. Austral. 2002; 177 (9): 50—51.
5. Papi A., Message S.D., Papadopoulos N.G. Respiratory viruses and asthma. Eur. Respir. Monogr. 2003; 8 (23): 223—238.
6. Szczeklik A., Picado C. Aspirin-induced asthma. Eur. Respir. Monog. 2003; 8 (23): 239—248.
7. Empey D.W. Mechanisms of bronchial hyperreactivity in normal subjects after upper respiratory tract infection. Am. Rev. Respir. Dis. 1976; 114 (1): 113—131.
8. Куделя Л.М., Сидорова Л.Д. Особенности местного и системного иммунитета у больных поздней астмой. В кн.: Тезисы докладов 10-го Национального конгресса по болезням органов дыхания. М.: 2000. 112.
9. Дидковский Н.А., Трескунов В.К., Захаржевская Т.В. Особенности клеточного иммунитета у больных бронхиальной астмой с непереносимостью аспирина. В кн.: Тезисы докладов 1-го Всесоюзного иммунологического съезда. М.: 1989. 45.
Review
For citations:
Sobchenko S.A., Schetchikova O.S., Yakovleva N.V. Acute non-atopic late-onset asthma induced by respiratory infection. PULMONOLOGIYA. 2005;(1):53-57. (In Russ.) https://doi.org/10.18093/0869-0189-2005-0-1-53-57
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