Effect of inhaled glucocorticosteroids on endothelial function and pulmonary and cardiac haemodynamics in patients with chronic obstructive pulmonary disease
https://doi.org/10.18093/0869-0189-2007-0-5-84-87
Abstract
Chronic obstructive pulmonary disease (COPD) is one of important problems of public healthcare. The aim of the present study was to investigate effect of beclomethazone on endothelial function (endothelin-1 level and results of Celermajer's test) and ultrasound parameters of pulmonary and central circulation in 42 COPD patients. Endothelium dysfunction was found in 66% of patients. It improved after antiinflammatory treatment. The improvement in myocardial diastolic function and decrease in systolic pulmonary artery pressure were revealed after 3-month beclomethazone therapy.
About the Authors
N. A. Kuzubova
НИИ пульмонологии Санкт-Петербургского государственного медицинского университета им. И.П.Павлова
Russian Federation
Russian Federation
V. E. Perley
НИИ пульмонологии Санкт-Петербургского государственного медицинского университета им. И.П.Павлова
Russian Federation
Russian Federation
A. Yu. Gichkin
НИИ пульмонологии Санкт-Петербургского государственного медицинского университета им. И.П.Павлова
Russian Federation
Russian Federation
E. A. Surkova
НИИ пульмонологии Санкт-Петербургского государственного медицинского университета им. И.П.Павлова
Russian Federation
Russian Federation
E. Yu. Lukina
НИИ пульмонологии Санкт-Петербургского государственного медицинского университета им. И.П.Павлова
Russian Federation
Russian Federation
References
1. Хроническая обструктивная болезнь легких. Федеральная программа. М.; 2004.
2. Шмелев Е.И. Хроническая обструктивная болезнь легких. Клинические рекомендации / Под ред. А.Г.Чучалина. М.; 2003. 117–122.
3. Singh J.M., Palda V.A. et al. Corticosteroid therapy for patients with exacerbations of chronic obstructive pulmonary disease: a systematic review. Arch. Intern. Med. 2005; 162: 2527–2536.
4. Куницина Ю.Л., Шмелев Е.И. Противовоспалительная терапия больных при хронической обструктивной болезни легких. Пульмонология 2003; 2: 111–116.
5. Jeffery P.K. Remodeling in asthma and COPD. Am. J. Respir. Crit. Care. 2001; 164: 28–38.
6. Roland M., Bhowmik A., Sapford R. et al. Sputum and plasma endothelin-1 levels in exacerbation of chronic obstructive pulmonary disease. Thorax 2001; 56: 30–35.
7. Celermajer D.S., Sorensen K.E., Gooch V.M. et al. Non-invasive detection of endothelial dysfunction children and adults at risk of atherosclerosis. Lancet 1992; 340 (8828): 1111–1115.
8. Weitzenblum E. Chronic cor pulmonale. Heart 2003; 89 (3): 225–230.
9. Humpert H., Sitbon O., Simonneau G. Treatment of pulmonary arterial hypertension. N. Engl. J. Med. 2004; 351: 1425–1436.
10. Kawut S.M., Palevsky H.I. New answers raise new questions in pulmonary arterial hypertension. Eur. Respir. J. 2004; 23: 799–801
11. Lee!Chiong T.L., Matthay R.A. In: Whitelaw W.A., Similowski T., Derenne J.-P. (eds.). Clinical management of chronic obstructive pulmonary disease. New York: Marcel Dekker Inc.; 2002. 475–544.
12. Zile M.R., Brutsaert D.I. New concepts in diastolic dysfunction and diastolic heart failure. Circulation 2002; 105 (6): 1387–1393.
Review
For citations:
Kuzubova N.A., Perley V.E., Gichkin A.Yu., Surkova E.A., Lukina E.Yu. Effect of inhaled glucocorticosteroids on endothelial function and pulmonary and cardiac haemodynamics in patients with chronic obstructive pulmonary disease. PULMONOLOGIYA. 2007;(5):84-87. (In Russ.) https://doi.org/10.18093/0869-0189-2007-0-5-84-87
Views:
266
Email this article 