Particularities of lung tumour angiogenesis and stroma formation in inhabitants from radionuclide-contaminated territories at Semipalatinsk region, Kazakhstan
https://doi.org/10.18093/0869-0189-2007-0-5-64-68
Abstract
The aim of this study was to investigate particularities of angiogenesis and stroma formation in various histological types of lung carcinoma in inhabitants from radionuclide-contaminated territories at Semipalatinsk region, Kazakhstan. We used operational and biopsy material from 87 lung carcinoma patients. Of them, 33 patients (the 1st group) lived in the neighbourhood of Semipalatinsk testing area from their childhood to 2002 and were exposed to radiation for a long time (the mean year radiation dose exceeded 0.1 rem). Operational and biopsy material from 54 patients living at Kazakhstan territories with normal radiation level (14 patients) or in Moscow (40 patients) were as controls (the 2nd group). Immunohistochemical methods were used to detect ММР-1, ММР-2, ММР-9, TIMP-1, VEGF, CD34, chromogranin, and CD68. Expression of ММР-1, ММР-2, ММР-9 in tumour cells was enhanced in the 1st group compared to the controls. Angiogenesis in tumour stroma of Semipalatinsk patients was more significant compared to the controls with regard to VEGF expression and density of newly formed vessels. We proposed that the mentioned above factors could provide poor prognosis of lung carcinoma in inhabitants of radionuclide-contaminated territories.
About the Authors
G. E. Sagindikova
ММА им. И.М.Сеченова
Russian Federation
Russian Federation
E. A. Kogan
ММА им. И.М.Сеченова
Russian Federation
Russian Federation
E. B. Satbaeva
Городской онкологический диспансер
Kazakhstan
Kazakhstan
References
1. Coussens L. M., Fingleton B., Matrisian L.M. Matrix metalloproteinase inhibitors and cancer: trials and tribulations. Science 2002; 295 (5564): 2387–2392.
2. Тюляндин С.А. Перспективные подходы лекарственной терапии немелкоклеточного рака легкого. В кн.: Новое в терапии рака легкого. М.; 2003.
3. Somerville R.P., Oblander S.A., Apte S. S. Matrix metalloproteinases: old dogs with new tricks. Genome Biology 2003; 4: 216.
4. Demedts I.K. et al. Role of apoptosis in the pathogenesis of COPD and pulmonary emphysema. Respir. Res. 2006; 7: 53.
5. Снарская Е.С., Молочков В.А., Франк Г.А., Завалишина Л.Э. Матриксные металлопротеиназы и их тканевые ингибиторы при базально-клеточном и метатипическом раке кожи. Арх. пат. 2005; 67 (3): 14–16.
6. Cox G., Steward W. P., O'Byrne K. J. The plasmin cascade and matrix metalloproteinases in non-small cell lung cancer. Thorax 1999; 54: 169–179.
7. Byun J.H., Lee M.A., Roh S.Y. Association between cyclooxygenase-2 and matrix metalloproteinase-2 expression in non-small cell lung cancer. Japan. J. Clin. Oncol. 2006; 36 (5): 263–268.
8. Cai M., Onoda K., Takao M. Degradation of tenascin-C and activity of matrix metalloproteinase-2 are associated with tumor recurrence in early stage non-small cell lung cancer. Clin. Cancer Res. 2002; 8: 1152–1156.
9. Laack E., Kohler A., Kugler C. Pretreatment serum levels of matrix metalloproteinase-9 and vascular endothelial growth factor in non-small-cell lung cancer. Ann. Oncol. 2002; 13: 1550–1557.
10. Pinto C.A., Carvalho P.E.O., Antonangelo L. Morphometric evaluation of tumor matrix metalloproteinase-9 predicts survival after surgical resection of adenocarcinoma of the lung. Clin. Cancer Res. 2003; 9: 3098–3104.
11. Shinya I., Takenaka K., Yanagihara K. Matrix metalloproteinase-2 status in stromal fibroblasts, not in tumor cells, is a significant prognostic factor in non-small-cell lung cancer. Clin. Cancer Res. 2004; 10: 6579–6585.
12. Hu Z., Huo X., Lu D. et al. Functional polymorphisms of matrix metalloproteinase-9 are associated with risk of occurrence and metastasis of lung cancer. Clin. Cancer Res. 2005; 11: 5433–5439.
13. Su L., Zhou W., Park S. Matrix metalloproteinase-1 promoter polymorphism and lung cancer risk. Cancer Epidemiol. Biomarkers Prevent. 2005; 14: 567–570.
14. Zhou Y., Yu C., Miao X. Functional haplotypes in the promoter of matrix metalloproteinase-2 and lung cancer susceptibility. Carcinogenesis 2005; 26 (6): 1117–1121.
15. Игембаева К.С. Последствия влияния ионизирующего излучения на клинику, течение и исход туберкулеза органов дыхания. Автореф. дис. … д-ра мед. наук. Семипалатинск; 2002.
16. Boume J. Handbook of immunoperoxidase staining methods. Santa Barbara: Dako Corp.; 1983.
Review
For citations:
Sagindikova G.E., Kogan E.A., Satbaeva E.B. Particularities of lung tumour angiogenesis and stroma formation in inhabitants from radionuclide-contaminated territories at Semipalatinsk region, Kazakhstan. PULMONOLOGIYA. 2007;(5):64-68. (In Russ.) https://doi.org/10.18093/0869-0189-2007-0-5-64-68
Views:
244
Email this article 