Quantitative change of regulatory T-lymphocytes in patients with chronic obstructive pulmonary disease
https://doi.org/10.18093/0869-0189-2013-0-3-25-30
Abstract
Summary. The study was aimed at investigation of regulatory T-lymphocytes (Treg) with CD4+CD25+CD127 phenotype in non-smoking and smoking patients with chronic obstructive pulmonary disease (COPD). We examined 21 non-smokers with COPD, 20 smokers with COPD, 20 healthy non-smokers, and 21 healthy smokers. T-lymphocyte subtypes were analyzed using flow cytometry. Treg percentage was significantly higher in non-smokers with COPD compared to non-smoking healthy controls. Blood Treg number in smokers with COPD was higher than in healthy smokers. Smokers with COPD had significantly higher proportion of Treg than non- smokers with COPD. We also found significant inverse correlation between Treg proportion and the CD8+ T-lymphocyte percentage in non-smoking COPD patients. The results of this study suppose a possible contribution of Treg to the systemic inflammation in COPD irrespectively of smoking.
About the Authors
A. G. Kadushkin
УО "Белорусский государственный медицинский университет"
Belarus
Belarus
T. V. Shman
ГУ "Республиканский научно-практический центр детской онкологии, гематологии и иммунологии"
Belarus
Belarus
V. P. Novikov
УЗ "Минский консультационно-диагностический центр"
Belarus
Belarus
Zh. A. Ibragimova
УО "Белорусский государственный медицинский университет"
Belarus
Belarus
A. D. Taganovich
УО "Белорусский государственный медицинский университет"
Belarus
Belarus
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Review
For citations:
Kadushkin A.G., Shman T.V., Novikov V.P., Ibragimova Zh.A., Taganovich A.D. Quantitative change of regulatory T-lymphocytes in patients with chronic obstructive pulmonary disease. PULMONOLOGIYA. 2013;(3):25-30. (In Russ.) https://doi.org/10.18093/0869-0189-2013-0-3-25-30
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