Preview

Пульмонология

Расширенный поиск

Рецепторы к интерлейкину-4 и -13: строение, функция и генетический полиморфизм

https://doi.org/10.18093/0869-0189-2010-3-113-119

Полный текст:

Об авторах

В. Н. Минеев
Кафедра госпитальной терапии им. акад. М.В.Черноруцкого Санкт-Петербургского государственного медицинского университета им. акад. И.П.Павлова
Россия


Л. Н. Сорокина
Кафедра госпитальной терапии им. акад. М.В.Черноруцкого Санкт-Петербургского государственного медицинского университета им. акад. И.П.Павлова
Россия


В. И. Трофимов
Кафедра госпитальной терапии им. акад. М.В.Черноруцкого Санкт-Петербургского государственного медицинского университета им. акад. И.П.Павлова
Россия


М. А. Нёма
Кафедра госпитальной терапии им. акад. М.В.Черноруцкого Санкт-Петербургского государственного медицинского университета им. акад. И.П.Павлова
Россия


В. А. Иванов
Кафедра госпитальной терапии им. акад. М.В.Черноруцкого Санкт-Петербургского государственного медицинского университета им. акад. И.П.Павлова
Россия


Список литературы

1. Paul W.E. Interleukin4: a prototypic immunoregulatory lymphokine. Blood 1991; 77: 1859-1870.

2. Кетлинский С.А., Симбирцев А.С. Цитокины. СПб.: Фолиант; 2008.

3. Zurawski G., de Vries J.E. Interleukin13, an interleukin-4-like cytokine that acts on monocytes and B cells, but not on T-cells. Immunol. Today 1994; 15: 19.

4. Burd P.R., Thompson W.C., Max E.E., Mills F.C. Activated mast cells produce interleukin 13. J. Exp. Med. 1995; 181: 1373.

5. Rinsho B. Involvement of interleukin4, and 13 in the pathogenesis of allergic diseases. 2001; 49 (4): 360-364.

6. Townley R.G., Horiba M. Airway hyperresponsiveness: a story of mice and men and cytokines. Clin. Rev. Allergy Immunol. 2003; 24 (1): 85-110.

7. Yang M., Hogan S.P., Henry P.J. et al. Interleukin13 mediates airways hyperreactivity through the IL4 receptor-alpha-chain and STAT6 independently of IL5 and eotaxin. Am.

8. J. Respir. Cell Mol. Biol. 2001; 25 (4): 522-530.

9. Wills:Karp M. Interleukin13 in asthma pathogenesis. Curr. Allergy Asthma Rep. 2004; 4 (2): 123-131.

10. Ip W.K., Wong C.K., Lam C.W. Interleukin (IL)4 and IL-3 upregulate monocyte chemoattractant protein-1 expression in human bronchial epithelial cells: involvement of p38 mitogenactivated protein kinase, extracellular signalregulated kinase 1/2 and Janus kinase2 but not cJun NH2terminal kinase 1/2 signalling pathways. Clin. Exp. Immunol. 2006; 145 (1): 162-172.

11. Тотолян А.А., Фрейдлин И.С. Клетки иммунной системы. СПб.: Наука; 2001; т. 3: 98-107.

12. Andrews A.L., Holloway J.W., Holgate S.T., Davies D.E. IL-4 receptor alpha is an important modulator of IL4 and IL-13 receptor binding: implications for the development of therapeutic targets. J. Immunol. 2006; 176: 7456-7461.

13. Kelly:Welch A.E., Hanson E.M., Boothby M.R., Keegan A.D. Interleukin-4 and interleukin13 signaling connections maps. Science 2003; 300: 1527-1528.

14. Mueller T.D., Zhang J.L., Sebald W., Duschl A. Structure, binding, and antagonists in the IL4 / IL13 receptor sys tem. Biochim. Biophys. Acta 2002; 1592: 237-250.

15. Минеев В.Н., Сорокина Л.Н. Современные представле ния о JAKSTAT системе как новой сигнальной системе и ее нарушениях при иммунной патологии (Часть I). Аллергология 2005; 4: 38-44.

16. Минеев В.Н., Сорокина Л.Н. Современные представления о JAKSTAT системе как новой сигнальной системе и ее нарушениях при иммунной патологии: механизмы негативной регуляции (Часть II). Аллергология 2006; 1: 49-55.

17. Kraich M., Klein M., Patiсo E. et al. A modular interface of IL-4 allows for scalable affinity without affecting specificity for the IL4 receptor. BMC Biol. 2006; 26 (4): 13.

18. Chomarat P., Banchereau J. An update on interleukin4 and its receptor. Eur. Cytokine Netw. 1997; 8 (4): 333-344.

19. Chomarat P., Banchereau J. Interleukin4 and interleukin-13: their similarities and discrepancies. Int. Rev. Immunol. 1998; 17 (1-4): 1-52.

20. Hershey G.K. IL13 receptors and signaling pathways: an evolving web. J. Allergy Clin. Immunol. 2003; 111 (4): 677-690.

21. Barnes P.J. The cytokine network in asthma and chronic obstructive pulmonary disease. J. Clin. Invest. 2008; 118 (11): 3546-3556.

22. Nicola M.H., Xiulan Qi, Ilkka S. et al. Type I IL4Rs selectively activate IRS2 to induce target gene expression in macrophages. Sci. Signal. 2008; 1: 17.

23. Andrews A.L., Holloway J.W., Puddicombe S.M. et al. Kinetic analysis of the interleukin-13 receptor complex. J. Biol. Chem. 2002; 277: 46073-46078.

24. Sato T A., Widmer M.B., Finkelman F.D. et al. Recombinant soluble murine IL4 receptor can inhibit or enhance IgE responses in vivo. J. Immunol. 1993; 150: 2717-2725.

25. Borish L.C., Nelson H.S., Corren J. et al. Efficacy of soluble IL-4 receptor for the treatment of adults with asthma. J. Allergy Clin. Immunol. 2001; 107: 963-970.

26. Boulay J.L., O'Shea J.J., Paul W.E. Molecular phylogeny within type I cytokines and their cognate receptors. Immunity. 2003; 19: 159-163.

27. Arima K., Sato K., Tanaka G. et al. Characterization of the interaction between interleukin-13 and interleukin-13 receptors. J. Biol. Chem. 2005; 280: 24915-24922.

28. Caput D., Laurent P., Kaghad et al. Cloning and characterization of a specific interleukin (IL)13 binding protein structurally related to the IL5 receptor ƒchain. J. Biol. Chem. 1996; 271: 16921.

29. LaPorte S.L., Sean Juo Z., Vaclavikova J. et al. Molecular and structural basis of cytokine receptor pleiotropy in the interleukin-4 / -13 system. Cell 2008; 132 (2): 259-272.

30. Umeshita:Suyama R., Sugimoto R., Akaiwa M. et al. Characterization of IL4 and IL13 signals dependent on the human IL13 receptor ƒchain 1: redundancy of requirement of tyrosine residue for STAT3 activation. Int. Immunol. 2000; 12 (11): 1499-1509.

31. Zdanov A., Wlodawe A. A. New look at cytokine signaling. Cell 2008; 132: 179-181.

32. Zhang J.L., Buehner M., Sebald W. Functional epitope of common gamma chain for interleukin4 binding. Eur. J. Biochem. 2002; 269: 1490-1499.

33. Miloux B., Laurent P., Bonnin O. et al. Cloning of the human IL-13R alpha1 chain and reconstitution with the IL4-R-alpha of a functional IL4 / IL13 receptor complex. FEBS Lett. 1997; 401: 163-166.

34. Obiri W., Debinski W.J., Leonard R.K. et al. Receptor for interleukin-13. Interaction with interleukin4 by a mechanism that does not involve the common gamma chain shared by receptors for interleukins 2, 4, 7, 9, and 15. J. Biol. Chem. 1995; 270: 8797-8804.

35. Фрейдин М.Б., Брагина Е.Ю., Огородова Л.М., Пузырев В.П. Генетика атопии: современное состояние. Вестн. Все рос. о-ва генетиков и селекционеров 2006; 10 (3): 492-503.

36. Hoffjan S., Ober C. Present status on the genetic studies of asthma. Curr. Opinion Immunol. 2002; 14: 709-717.

37. Deichmann K., Bardutzky J., Forster J. et al. Common polymorphisms in the coding part of the IL-4 receptor gene. Biochem. Biophys. Res. Commun. 1997; 231: 696-697.

38. Hershey G.K., Friedrich M.F., Esswein L.A. et al. The association of atopy with a gainoffunction mutation in the alpha subunit of the interleukin4 receptor. N. Engl. J. Med. 1997; 337: 1720-1725.

39. Ober C., Leavitt S.A., Tsalenko A. et al. Variation in the interleukin-4 receptor alpha gene confers susceptibility to asthma and atopy in ethnically diverse populations. Am. J. Hum. Genet. 2000; 66: 517-526.

40. Wu X., Di Rienzo A., Ober C. A population genetics study of single nucleotide polymorphisms in the interleukin 4 receptor alpha (IL4RA) gene. Genes Immun. 2001; 2: 128-134.

41. Mitsuyasu H., Yanagihara Y., Mao X.Q. et al. Cutting edge: dominant effect of Ile50Val variant of the human IL4 receptor alphachain in IgE synthesis. J. Immunol. 1999; 162: 1227-1231.

42. Izuhara K., Yanagihara Y., Hamasaki N. et al. Atopy and the human IL4 receptor alpha chain. J. Allergy Clin. Immunol. 2000; 106: S65S71.

43. Oiso N., Fukai K., Ishii M. Interleukin 4 receptor alpha-chain polymorphism Gln551Arg is associated with adult atopic dermatitis in Japan. Br. J. Dermatol. 2000; 142: 1003-1006.

44. Haagerup A., Bjerke T., Schiotz P.O. et al. No linkage and association of atopy to chromosome 16 including the interleukin-4 receptor gene. Allergy 2001; 56: 775-779.

45. Hershey G.K., Friedrich M.F., Esswein L.A. et al. The association of atopy with a gainoffunction mutation in the subunit of the interleukin-4 receptor. N. Engl. J. Med. 1997; 337: 1720-1725.

46. Wang H.Y., Shelburne C.P., Zamorano J. et al. Cutting edge: effects of an allergyassociated mutation in the transduction human IL- 4R alpha (Q576R) on human IL-4 induced signal. J. Immunol. 1999; 162: 4385-4389.

47. Kruse S., Japha T., Tedner M. et al. The polymorphisms S503P and Q576R in the interleukin4 receptor alpha gene are associated with atopy and influence the signal transduction. Immunology 1999; 96: 365-371.

48. Howard T.D., Koppelman G.H., Xu J. et al. Genegene interaction in asthma: a Dutch population with asthma. Am. J. Hum. Genet. 2002; 70: 230-236.

49. Hackstein H., Hecker M., Kruse S. et al. A novel polymorphism in the 52 promoter region of the human interleukin-4 receptor alphachain gene is associated with decreased soluble interleukin4 receptor protein levels. Immunogenetics 2001; 53 (4): 264-269.

50. Jung T., Wagner K., Neumann C., Heusser C.H. Enhancement of human IL4 activity by soluble IL4 receptors in vitro. Eur. J. Immunol. 1999; 29: 864-871.

51. Howard T.D., Whittaker P.A., Zaiman A.L. et al. Identification association of polymorphisms in the interleukin-13 gene with and asthma and atopy in a Dutch population. Am. J. Respir. Cell Mol. Biol. 2001; 25: 377-384.

52. Heinzmann A., Mao X.Q., Akaiwa M. et al. Genetic variants of IL-13 signalling and human asthma and atopy. Hum. Mol. Genet. 2000; 9: 549-559.

53. Ahmed S., Ihara K., Sasaki Y. et al. Novel polymorphism in the coding region of the IL-13 receptor alpha gene: association study with atopic asthma in the Japanese population. Exp. Clin. Immunogenet. 2000; 17: 18-22.

54. Obiri N. I., Hillman G.G., Haas G.P. et al. Expression of high affinity interleukin4 receptors on human renal cell carcinoma cells and inhibition of cell growth in vitro by interleukin J. Clin. Invest. 1993; 91: 88-93.

55. Puri R.K., Leland P., Kreitman R., Pastan I. Human neuro logical cancer cells express interleukin-4 (IL-4) receptors which are targets for the toxic effects of IL-4P seudomonas exotoxin chimeric protein. Int. J. Cancer 1994; 58: 574-581.

56. Obiri N.I., Siegel J.P., Varricchio F., Puri R.K. Expression of highaffinity IL4 receptors on human melanoma, ovarian and breast carcinoma cells. Clin. Exp. Immunol. 1994; 95: 148-155.

57. Kawakami M., Kawakami K., Stepensky V.A. et al. Interleukin 4 receptor on human lung cancer: a molecular target for cytotoxin therapy. Clin. Cancer Res. 2002; 8 (11): 3503-3511.

58. Grzela K., Grzela T., Korczak:Kowalska G. et al. Risk of allergy development correlates with IL4 receptor expression on newborns' monocytes and Th-lymphocytes. Med. Sci. Monit. 2007; 13 (10): CR445-СR448.

59. Kotsimbos T.C., Ghaffar O., Minshall E.M. et al. Expression of the IL4 receptor alphasubunit is increased in bronchial biopsy specimens from atopic and nonatopic asthmatic subjects. J. Allergy Clin. Immunol. 1998; 102 (5): 859-866.


Для цитирования:


Минеев В.Н., Сорокина Л.Н., Трофимов В.И., Нёма М.А., Иванов В.А. Рецепторы к интерлейкину-4 и -13: строение, функция и генетический полиморфизм. Пульмонология. 2010;(3):113-119. https://doi.org/10.18093/0869-0189-2010-3-113-119

Просмотров: 13


ISSN 0869-0189 (Print)
ISSN 2541-9617 (Online)