Особенности структуры и функции респираторного эпителия при бронхиальной астме


https://doi.org/10.18093/0869-0189-2012-0-5-85-91

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Аннотация

Особенности структуры и функции респираторного эпителия при бронхиальной астме.


Об авторах

А. Ю. Конищева
ФГБУ "НИИВС им. И.И.Мечникова" РАМН
Россия

к. м. н., старший научный сотрудник лаборатории аллергодиагностики

105064, Москва, М. Казенный пер., 5а. Тел. / факс: (495) 917-20-26.



В. Б. Гервазиева
ФГБУ "НИИВС им. И.И.Мечникова" РАМН
Россия

д. м. н., проф., зав. лабораторией аллергодиагностики

105064, Москва, М. Казенный пер., 5а. Тел. / факс: (495) 917-20-26.



Е. Е. Лаврентьева
ФГБУ "НИИВС им. И.И.Мечникова" РАМН
Россия

аспирант лаборатории аллергодиагностики

105064, Москва, М. Казенный пер., 5а. Тел. / факс: (495) 917-20-26.



Список литературы

1. Гриппи М. А. Патофизиология легких. М.; 2000. 87–95.

2. Rogan M.P., Geraghty P., Greene C.M. et al. Antimicrobial proteins and polypeptides in pulmonary innate defence. Respir. Res. 2006; 7(1): 29.

3. Knight D.A., Holgate S.T. The airway epithelium: structural and functional properties in health and disease. Respirology 2003; 8: 432–446.

4. Holgate S.T. The sentinel role of the airway epithelium in asthma pathogenesis. Immunol. Rev. 2011; 242 (1): 205–219.

5. de Heer H. J., Hammad H., Kool M. et al. Dendritic cell subsets and immune regulation in the lung. Semin. Immunol. 2005; 17: 295–303.

6. Hasegawa M., Fujimoto M., Hamaguchi Y. et al. Use of serum Clara cell 16kDa (CC16) levels as a potential indicator of active pulmonary fibrosis in systemic sclerosis. J. Rheumatol. 2011; 38 (5): 877–884.

7. Lomas D.A., Silverman E.K., Edwards L.D. et al. Evaluation of serum CC16 as a biomarker for COPD in the ECLIPSE cohort. Thorax 2008; 63 (12): 1058–1063.

8. Davies D.E., Wicks J., Powell R.M. et al. Airway remodeling in asthma: new insights. J. Allergy Clin. Immunol. 2003; 111 (2): 215–225.

9. Cunningham R., Mahon B.P. The immunological role of respiratory tract epithelium. Mod. Aspects Immunobiol. 2001; 1 (5): 204–209.

10. Warburton D., Schwarz M., Tefft D. et al. The molecular basis of lung morphogenesis. Mech. Dev. 2000; 92: 55–81.

11. Agrawal D.K., Shao Z. Pathogenesis of allergic airway in flammation. Curr. Allergy Asthma Rep. 2010; 10 (1): 39–48.

12. Lambrecht B.N., Hammad H. The role of dendritic and epithelial cells as master regulators of allergic airway inflammation. Lancet 2010; 376 (9743): 835–843.

13. Oettgen H.C., Geha R.S. IgE regulation and roles in asthma pathogenesis. J. Allergy Clin. Immunol. 2001; 107 (3): 429–440.

14. Krishnamoorthy N., Oriss T.B., Paglia M. et al. Activation of cKit in dendritic cells regulates T helper cell differentiation and allergic asthma. Nature Med. 2008; 14: 565–573.

15. Tan A.M., Chen H.C., Pochard P. et al. TLR4 signaling in stromal cells is critical for the initiation of allergic Th2 responses to inhaled antigen. J. Immunol. 2010; 184 (7): 3535–3544.

16. Ritz S.A., Stampfli M.R., Davies D.E. et al. On the generation of allergic airway diseases: from GMCSF to Kyoto. Trends Immunol. 2002; 23: 396–402.

17. Kisic A., Sutanto E.N., Stevens P.T. Intrinsic biochemical and functional differences in bronchial epithelial cells of children with asthma. Am. J. Respir. Crit. Care Med. 2006; 174: 1110–1118.

18. Hashimoto S., Matsumoto K., Gon Y. Update on airway inflammation and remodeling in asthma. Allergy Clin. Immunol. Int. – J. Wld Allergy Org. 2007; 19: 178–184.

19. Poynter M.E., Irvin C.G., Janssen/Heininger Y.M. A prominent role for airway epithelial NFkappa B activation in lipopolysaccharideinduced airway inflammation. J. Immunol. 2003; 170 (12): 6257–6265.

20. Skerrett S.J., Liggitt H.D., Hajjar A.M. et al. Respiratoryepithelial cells regulate lung inflammation in response to inhaled endotoxin. Am. J. Physiol. Lung Cell. Mol. Physiol. 2004; 287 (1): L143– L152.

21. Perros F., Lambrecht B.N., Hammad H. TLR4 signalling in pulmonary stromal cells is critical for inflammation and immunity in the airways Respir. Res. 2011; 12 (1): 125.

22. Iwamura C., Nakayama T. Tolllike receptors in the respiratory system: their roles in inflammation. Curr. Allergy Asthma Rep. 2008; 8 (1): 7–13

23. Phipps S., Lam C.E., Kaiko G.E. et al. Toll/IL1 signaling is critical for house dust mitespecific helper T cell type 2 and type 17 responses. Am. J. Respir. Crit. Care Med. 2009; 179 (10): 883–893.

24. Trompette A., Divanovic S., Visintin A. et al. Allergenicityresulting from functional mimicry of a Tolllike receptor complex protein. Nature 2009; 457: 585–588.

25. Hammad H., Chieppa M., Perros F. et al. House dust miteallergen induces asthma via Tolllike receptor 4 triggering of airway structural cells. Nature Med. 2009; 15: 410–416.

26. Holtzman M.J., Morton J.D., Shornick L.P. Immunity, inflammation, and remodeling in the airway epithelial barrier: epithelialviralallergic paradigm. Physiol. Rev. 2002; 82: 19–46.

27. Wark P.A., Johnston S.L., Bucchieri F. Asthmatic bronchial epithelial cells have a deficient innate immune response to infection with rhinovirus. J. Exp. Med. 2005; 201 (6): 937–947.

28. Wegmann M., Fehrenbach H., Fehrenbach A. et al. Involvement of distal airways in a chronic model of experimental asthma. Clin. Exp. Allergy 2005; 35: 1263–1271.

29. Takizawa H. Bronchial epithelial cells in allergic reactions. Curr. Drug Targets Inflamm. Allergy 2005; 4 (3): 305–311.

30. Tai H.Y., Tam M.F., Chou H. Pen ch 13 allergen induces secretion of mediators and degradation of occludin protein of human lung epithelial cells. Allergy 2006; 61: 382–388.

31. Чучалин А. Г. (ред.). Бронхиальная астма. М.: Агар; 1997; т. 2: 199–226.

32. Descalzi D., Folli C. Современные представления о процессах ремоделирования стенок дыхательных путей. Allergy Clin. Immunol. Int. – J. Wld Allergy Org. Russ. Ed., пер.с. англ., 2/2, 2007. 6–10.

33. Pohunek P., Warner J.O., Turzikova J. et al. Markers ofeosinophilic inflammation and tissue remodelling in children before clinically diagnosed bronchial asthma. Pediatr. Allergy Immunol. 2005; 16: 43–51.

34. Kuwano K. Epithelial cell apoptosis and lung remodeling. Cell. Mol. Immunol. 2007; 4 (6): 419–429.

35. Xia Y., Schneyer A.L. The biology of activin: recent advances in structure, regulation and function. J. Endocrinol. 2009; 202: 1–12.

36. Ota F., Maeshima A., Yamashita S. et al. Activin A induces cell proliferation of fibroblastlike synoviocytes in rheuma toid arthritis. Arthr. and Rheum. 2003; 48: 2442–2449.

37. Jones K.L., de Kretser D.M., Patella S. et al. Activin A and follistatin in systemic inflammation. Mol. Cell. Endocrinol. 2004; 225: 119–125.

38. Ogawa K., Funaba M., Chen Y. et al. Activin A functions as a Th2 cytokine in the promotion of the alternative activation of macrophages. J. Immunol. 2006; 177: 6787–6794.

39. Cho S.H., Yao Z., Wang S.W. et al. Regulation of activin A expression in mast cells and asthma: its effect on the proliferation of human airway smooth muscle cells. J. Immunol. 2003; 170: 4045–4052.

40. Karagiannidis C., Hense G., Martin C. et al. Activin A is an acute allergenresponsive cytokine and provides a link to TGFbetamediated airway remodeling in asthma. J. Allergy Clin. Immunol. 2006; 117: 111–118.

41. Hardy C.L., O'Connor A.E., Yao J. et al. Follistatin is a candidate endogenous negative regulator of activin A in experimental allergic asthma. Clin. Exp. Allergy 2006; 36: 941–950.

42. Semitekolou M., Alissafi T., Aggelakopoulou M. et al. Activin A induces regulatory T cells that suppress T helper cell immune responses and protect from allergic airway disease. J. Exp. Med. 2009; 206: 1769–1785.

43. Chen Y., Wu H., Winnall W.R. et al. Tumour necrosis factorα stimulates human neutrophils to release preformed activin A. Immunol. Cell Biol. 2011; 89 (8): 889–896.


Дополнительные файлы

Для цитирования: Конищева А.Ю., Гервазиева В.Б., Лаврентьева Е.Е. Особенности структуры и функции респираторного эпителия при бронхиальной астме.  Пульмонология. 2012;(5):85-91. https://doi.org/10.18093/0869-0189-2012-0-5-85-91

For citation: Konishcheva A.Y., Gervazieva V.B., Lavrentyeva E.E. Changes in structure and function of respiratory epithelium in bronchial asthma. Russian Pulmonology. 2012;(5):85-91. (In Russ.) https://doi.org/10.18093/0869-0189-2012-0-5-85-91

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ISSN 0869-0189 (Print)
ISSN 2541-9617 (Online)