Arterial stiffness in patients with interstitial lung diseases
https://doi.org/10.18093/0869-0189-2019-29-5-582-589
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Abstract
The aim of this study was to investigate arterial wall stiffness and its relationship with right ventricle systolic function (RVSF) in patients with interstitial lung disease. Methods. Fifty patients with chronic hypersensitivity pneumonitis (HP) and 26 patients with idiopathic pulmonary fibrosis (IPF) were included. Spirometry, body plethysmography were performed, lung diffusion capacity for carbon monoxide (DLCO), blood gases and arterial wall stiffness were measured. High resolution computed tomography (HRCT) of the chest was assessed using Kazerooni scale. Results. The aortic pulse wave velocity (PWV, m/s) was increased in 26 (52%) patients with HP and in 14 patients with IPF. Correlation analysis showed statistically significant association between PWVАo and DLCO (p < 0.05), partial oxygen pressure in the arterial blood (PaO2) (p < 0.05), pulmonary fibrosis (p = 0.001), and the extension of ground glass opacities (p < 0.05). Tricuspid annual plane systolic excursion (TAPSE), right ventricular myocardial performance index (MPI) and tricuspid annular systolic velocity (S’) were significantly related to PWVАo, ambulatory arterial stiffness index (AASI) and augmentation index (AIx) (p < 0.05). Conclusion. Increased arterial stiffness was often found in patients with HP and IPF. The increased arterial stiffness is associated with hypoxemia, pulmonary fibrosis and decreased lung diffusion capacity. The arterial stiffness is also related to the right ventricular systolic dysfunction.
About the Authors
E. I. Leonova
Federal Central Research Institute of Tuberculosis, Russian Academy of Science
Russian Federation
Russian Federation
Elena I. Leonova - Candidate of Medicine, Researcher, Division of Differential Diagnosis of Tuberculosis and Extracorporeal Therapeutic Methods, Federal Central Research Institute of Tuberculosis, Russian Academy of Science.
Yauzskaya alleya 2, Moscow, 107564.
tel.: (906) 755-36-54E. I. Shmelev
Federal Central Research Institute of Tuberculosis, Russian Academy of Science
Russian Federation
Russian Federation
Evgeniy I. Shmelev - Doctor of Medicine, Professor, Head of Division of Differential Diagnosis of Tuberculosis and Extracorporeal Therapeutic Methods, Federal Central Research Institute of Tuberculosis, Russian Academy of Science.
Yauzskaya alleya 2, Moscow, 107564.
tel.: (499) 785 90-31E. A. Shergina
Federal Central Research Institute of Tuberculosis, Russian Academy of Science
Russian Federation
Russian Federation
Elena A. Shergina - Candidate of Medicine, Head of Department of Functional Diagnosis, Federal Central Research Institute of Tuberculosis, Russian Academy of Science.
Yauzskaya alleya 2, Moscow, 107564.
tel.: (499) 785-90-48References
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Leonova E.I., Shmelev E.I., Shergina E.A. Arterial stiffness in patients with interstitial lung diseases. PULMONOLOGIYA. 2019;29(5):582-589. (In Russ.) https://doi.org/10.18093/0869-0189-2019-29-5-582-589
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ISSN 0869-0189 (Print)
ISSN 2541-9617 (Online)
ISSN 2541-9617 (Online)
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