Arterial stiffness in patients with interstitial lung diseases
https://doi.org/10.18093/0869-0189-2019-29-5-582-589
Abstract
The aim of this study was to investigate arterial wall stiffness and its relationship with right ventricle systolic function (RVSF) in patients with interstitial lung disease. Methods. Fifty patients with chronic hypersensitivity pneumonitis (HP) and 26 patients with idiopathic pulmonary fibrosis (IPF) were included. Spirometry, body plethysmography were performed, lung diffusion capacity for carbon monoxide (DLCO), blood gases and arterial wall stiffness were measured. High resolution computed tomography (HRCT) of the chest was assessed using Kazerooni scale. Results. The aortic pulse wave velocity (PWV, m/s) was increased in 26 (52%) patients with HP and in 14 patients with IPF. Correlation analysis showed statistically significant association between PWVАo and DLCO (p < 0.05), partial oxygen pressure in the arterial blood (PaO2) (p < 0.05), pulmonary fibrosis (p = 0.001), and the extension of ground glass opacities (p < 0.05). Tricuspid annual plane systolic excursion (TAPSE), right ventricular myocardial performance index (MPI) and tricuspid annular systolic velocity (S’) were significantly related to PWVАo, ambulatory arterial stiffness index (AASI) and augmentation index (AIx) (p < 0.05). Conclusion. Increased arterial stiffness was often found in patients with HP and IPF. The increased arterial stiffness is associated with hypoxemia, pulmonary fibrosis and decreased lung diffusion capacity. The arterial stiffness is also related to the right ventricular systolic dysfunction.
About the Authors
E. I. Leonova
Federal Central Research Institute of Tuberculosis, Russian Academy of Science
Russian Federation
Russian Federation
Elena I. Leonova - Candidate of Medicine, Researcher, Division of Differential Diagnosis of Tuberculosis and Extracorporeal Therapeutic Methods, Federal Central Research Institute of Tuberculosis, Russian Academy of Science.
Yauzskaya alleya 2, Moscow, 107564.
tel.: (906) 755-36-54E. I. Shmelev
Federal Central Research Institute of Tuberculosis, Russian Academy of Science
Russian Federation
Russian Federation
Evgeniy I. Shmelev - Doctor of Medicine, Professor, Head of Division of Differential Diagnosis of Tuberculosis and Extracorporeal Therapeutic Methods, Federal Central Research Institute of Tuberculosis, Russian Academy of Science.
Yauzskaya alleya 2, Moscow, 107564.
tel.: (499) 785 90-31E. A. Shergina
Federal Central Research Institute of Tuberculosis, Russian Academy of Science
Russian Federation
Russian Federation
Elena A. Shergina - Candidate of Medicine, Head of Department of Functional Diagnosis, Federal Central Research Institute of Tuberculosis, Russian Academy of Science.
Yauzskaya alleya 2, Moscow, 107564.
tel.: (499) 785-90-48References
1. Dalleywater W., Powell H.A., Hubbard R.B., Navaratnam V. Risk factors for cardiovascular disease in people with idiopathic pulmonary fibrosis. Chect. 2015; 147 (1): 150–156. DOI: 10.1378/chest.14-0041.
2. Rivera-Lebron B.N., Forfia P.R., Kreider M. et al. Echocardiographic and hemodynamic predictors of mortality in idiopathic pulmonary fibrosis. Chest. 2013; 144 (2): 564–570. DOI: 10.1378/chest.12-2298.
3. Akintunde A.A. Right ventricular function in patients with heart failure in a cardiac clinic in Southwest Nigeria. Nigerian Med. J. 2017; 58 (1): 7–12. DOI: 10.4103/0300-1652.218411.
4. Ben-Shlomo Y., Spears M., Boustred C. et al. Aortic pulse wave velocity improves cardiovascular event prediction: an individual participant meta-analysis of prospective observational data from 17,635 subjects. J. Am. Coll. Cardiol. 2014; 63 (7): 636–646. DOI: 10.1016/j.jacc.2013.09.063.
5. Vlachopoulos C., Aznaouridis K., Stefanadis C. Prediction of cardiovascular events and all-cause mortality with arterial stiffness: a systematic review and meta-analysis. J. Am. Coll. Cardiol. 2010; 55 (13): 1318–1327. DOI: 10.1016/j.jacc.2009.10.061.
6. Vriz O., Magne J., Jarosh J. et al. Local carotid arterial stiffness is an independent determinant of left ventricular remodeling in never-treated hypertensive patients. Blood Press. 2019; 28 (1): 23–33. DOI: 10.1080/08037051.2018.1511369.
7. Al-Naamani N., Chirinos J.A., Zamani P. et al. Association of Systemic Arterial Properties with Right Ventricular Morphology: The Multi-Ethnic Study of Atherosclerosis (MESA) – Right Ventricle Study. J. Am. Heart Assoc. 2016; 5 (12): pii: e004162. DOI: 10.1161/JAHA.116.004162.
8. Raghu G., Remy-Jardin M., Myers J.L. et al. Diagnosis of idiopathic pulmonary f ibrosis. An Off icial ATS/ERS/ JRS/ALAT Clinical Practice Guideline. Am. J. Respir. Crit. Care Med. 2018; 198 (5): е44–68. DOI: 10.1164/rccm.201807-1255ST.
9. Chuchalin A.G., Avdeev S.N., Aisanov Z.R. et al. [Diagnosis and Treatment of Idiopathic Pulmonary Fibrosis: Federal Guidelines]. Pul'monologiya. 2016; 26 (4): 399–419. DOI: 10.18093/0869-0189-2016-26-4-399-419 (in Russian).
10. Panagiotou M., Church A.C., Johnson M.K., Peacock A.J. Pulmonary vascular and cardiac impairment in interstitial lung disease. Eur. Respir. Rev. 2017; 26 (143): pii: 160053. DOI: 10.1183/16000617.0053-2016.
11. Van Bortel L.M., Laurent S., Boutouyrie P. et al. Expert consensus document on the measurement of aortic stiffness in daily practice using carotid-femoral pulse wave velocity. J. Hypertens. 2012; 30 (3): 445–448. DOI: 10.1097/HJH.0b013e32834fa8b0.
12. Townsend R.R., Wilkinson I.B., Schiffrin E.L. et al. Recommendations for improving and standardizing vascular research on arterial stiffness: a scientific statement from the American Heart Association. J. Hypertens. 2015; 66 (3): 698–722. DOI: 10.1161/HYP.0000000000000033.
13. Rudski L.G., Lai W.W., Afilalo J. et al. Guidelines for the echocardiographic assessment of the right heart in adults: a report from the American Society of Echocardiography, a registered branch of the European Society of Cardiology, and the Canadian Society of Echocardiography. J. Am. Soc. Echocardiogr. 2010; 23 (7): 685–713. DOI: 10.1016/j.echo.2010.05.010.
14. Lang R.M., Badano L.P., Mor-Avi V. et al. Recommendations for cardiac chamber quantification by echocardiography in adults: an update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging. J. Am. Soc. Echocardiogr. 2015; 28 (1): 1–39.е14. DOI: 10.1016/j.echo.2014.10.003.
15. Galderisi M., Cosyns B., Edvardsen T. et al. Standardization of adult transthoracic echocardiography reporting in agreement with recent chamber quantification, diastolic function, and heart valve disease recommendations: an expert consensus document of the European Association of Cardiovascular Imaging. Eur. Heart J. Cardiovasc. Imag. 2017; 18 (12): 1301–1310. DOI: 10.1093/ehjci/jex244.
16. Kolb T.M., Hassoun P.M. Right Ventricular Dysfunction in Chronic Lung Disease. Cardiol. Clin. 2012; 30 (2): 243–256. DOI: 10.1016/j.ccl.2012.03.005.
17. Hsia C.C. Cardiopulmonary limitations to exercise in restrictive lung disease. Med. Sci. Sports Exerc. 1999; 31 (1, Suppl.): S28–32. DOI: 10.1097/00005768-199901001-00005.
18. Cottin V., Le Pavec J., Prévot G. et al. Pulmonary hypertension in patients with combined pulmonary fibrosis and emphysema syndrome. Eur. Respir. J. 2010; 35 (1): 105–111. DOI: 10.1183/09031936.00038709.
19. Broder M., Change E., Papoyan E. et al. Risk of cardiovascular comorbidities in patients with idiopathic pulmonary fibrosis: analysis of Medicare data. Eur. Respir. J. 2016; 48 (Suppl. 60): PA4919. DOI: 10.1183/13993003.congress-2016.PA4919.
20. Petersons C.J., Mangelsdorf B.L., Poljak A. et al. Low dose prednisolone and insulin sensitivity differentially affect arterial stiffness and endothelial function: an open interventional and cross-sectional study. Atherosclerosis. 2017; 258: 34–39. DOI: 10.1016/j.atherosclerosis.2017.01.033.
21. Karoli N.A., Dolishnyaya G.R., Rebrov A.P. [Diurnal arterial stiffness in males with different phenotypes of chronic obstructive pulmonary disease and hypertension comorbidity]. Klinicist. 2015; 9 (1): 37–41. DOI: 10.17650/1818-8338-2015-1-37-41 (in Russian).
22. Makarova M.A., Avdeev S.N., Chuchalin A.G. [Hypoxemia as a potential risk factor for endothelial dysfunction and arterial stiffness in patients with chronic obstructive pulmonary disease]. Pul'monologiya. 2013; (3): 36–40 (in Russian).
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Leonova E.I., Shmelev E.I., Shergina E.A. Arterial stiffness in patients with interstitial lung diseases. PULMONOLOGIYA. 2019;29(5):582-589. (In Russ.) https://doi.org/10.18093/0869-0189-2019-29-5-582-589
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