Particle pollution as a risk factor for lung carcinoma
https://doi.org/10.18093/0869-0189-2019-29-4-477-485
Abstract
Current view on a relationship between particle pollution, morbidity and mortality of lung carcinoma were discussed in the article. Published epidemiological, clinical and laboratory studies suggest particle pollution, especially metal containing particulate matter (PM), to be a risk factor for lung carcinoma occurrence. PM-associated injury of epithelial cell genome and epigenetic lesions are an important part of pathogenesis of lung carcinoma. Systemic research findings and formalized reports could improve our knowledge on lung cancer pathogenesis and could be used in clinical practice for risk assessment, early detection and prognosis of lung cancer and improvement in treatment efficacy.
About the Authors
A. F. Kolpakova
Federal Research Institute of Computational Technologies, Siberian Department of Russian Academy of Science
Russian Federation
Russian Federation
Alla F. Kolpakova, Doctor of Medicine, Professor, Leading Researcher, Laboratory of Bioinformatics
ul. Akademika Rzhanova 6, Novosibirsk, 630090
R. N. Sharipov
BIOSOFT.RU LLC;
Novosibirsk National Research University
Russian Federation
Russian Federation
Ruslan N. Sharipov, Head of Projects, BIOSOFT.RU LLC, Senior Teacher, Novosibirsk National Research University
ul. Russkaya 41/1, Novosibirsk, 630058,
ul. Pirogova 2, Novosibirsk, 630090
O. A. Volkova
"Institute of Cytology and Genetics" Federal Research Center, Siberian Department of Russian Academy of Science
Russian Federation
Russian Federation
Oksana A. Volkova, Candidate of Biology, Researcher, Laboratory of Genetic Engineering
ul. Akademika Lavrent’yeva 10, Novosibirsk, 630090
F. A. Kolpakov
Federal Research Institute of Computational Technologies, Siberian Department of Russian Academy of Science;
BIOSOFT.RU LLC
Russian Federation
Russian Federation
Fedor A. Kolpakov, Candidate of Biology, Head of Laboratory of Bioinformatics, Federal Research Institute of Computational Technologies, Siberian Department of Russian Academy of Science; Engineering Director, BIOSOFT.RU LLC
ul. Akademika Rzhanova 6, Novosibirsk, 630090,
ul. Russkaya 41/1, Novosibirsk, 630058
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For citations:
Kolpakova A.F., Sharipov R.N., Volkova O.A., Kolpakov F.A. Particle pollution as a risk factor for lung carcinoma. PULMONOLOGIYA. 2019;29(4):477-485. (In Russ.) https://doi.org/10.18093/0869-0189-2019-29-4-477-485
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