Acute exacerbation of COPD and comorbid cardiovascular diseases
https://doi.org/10.18093/0869-0189-2019-29-4-468-476
Abstract
Chronic obstructive pulmonary disease (COPD) is a major public health problem worldwide. COPD is closely related to comorbid cardiovascular diseases, which contribute to the worsening of COPD and increased mortality. The frequency and prevalence of cardiovascular diseases in patients with COPD is about 64%. Approximately 30% of patients with COPD die from cardiovascular complications. Recent evidence suggests an increased risk of acute myocardial infarction in severe exacerbations of COPD. Tachycardia, increased oxidative stress and systemic inflammation in patients with COPD may contribute to an increased risk of developing cardiovascular complications. Several studies may be useful for early diagnosis, including electrocardiography, imaging methods, and biomarker blood tests. Some drugs that have changed the prognosis for cardiovascular disease, in particular, cardioselective beta-blockers, are underused in patients with COPD, despite proven benefits. This review focuses on some aspects of COPD exacerbation and the risk of cardiovascular disease.
About the Authors
E. Kh. Anaev
N.I.Pirogov Federal Russian National Research Medical University, Healthcare Ministry of Russia;
D.D.Pletnev City Teaching Hospital, Moscow Healthcare Department
Russian Federation
Russian Federation
El'dar Kh. Anaev, Doctor of Medicine, Professor, Department of Pulmonology, N.I.Pirogov Federal Russian National Research Medical University, Healthcare Ministry of Russia; pulmonologist, Moscow Research and Clinical Teaching Center of Respiratory Medicine, D.D.Pletnev City Teaching Hospital, Moscow Healthcare Department
ul. Ostrovityanova 1, Moscow, 117997,
ul. Odinnadtsataya Parkovaya 32, Moscow, 105077
I. L. Gorelik
D.D.Pletnev City Teaching Hospital, Moscow Healthcare Department
Russian Federation
Russian Federation
Irina L. Gorelik, Candidate of Medicine, physician, Department of Functional and Ultrasound Diagnostics
ul. Odinnadtsataya Parkovaya 32, Moscow, 105077
References
1. Corrao S., Brunori G., Lupo U., Perticone F. Effectiveness and safety of concurrent beta-blockers and inhaled bronchodilators in COPD with cardiovascular comorbidities. Eur. Respir. Rev. 2017; 26 (145): pii: 160123. DOI: 10.1183/16000617.0123-2016.
2. Mullerova H., Agusti A., Erqou S., Mapel D.W. Cardiovascular comorbidity in COPD: systematic literature review. Chest. 2013; 144 (4): 1163–1178. DOI: 10.1378/chest.12-2847.
3. Rothnie K.J., Connell O., Müllerová H. et al. Myocardial Infarction and Ischemic Stroke after Exacerbations of Chronic Obstructive Pulmonary Disease. Ann. Am. Thorac. Soc. 2018; 15 (8): 935–946. DOI: 10.1513/AnnalsATS.201710-815OC.
4. Aisanov Z.R., Avdeev S.N., Arkhipov V.V., et al. National Guidelines On Diagnosis And Treatment Of Chronic Obstructive Pulmonary Disease” An Algorithm For Making A Clinical Decision. Pul’monologiya. 2017; 27 (1): 13–20. DOI: 10.18093/0869-0189-2017-27-1-13-20. (in Russian).
5. Chen W., Thomas J., Sadatsafavi M., Fitz Gerald J.M. Risk of cardiovascular comorbidity in patients with chronic obstructive pulmonary disease: a systematic review and meta-analysis. Lancet Respir. Med. 2015; 3 (8): 631–639. DOI: 10.1016/S2213-2600(15)00241-6.
6. Berger J.S., Sanborn T.A., Sherman W., Brown D.L. Effect of chronic obstructive pulmonary disease on survival of patients with coronary heart disease having percutaneous coronary intervention. Am. J. Cardiol. 2004; 94 (5): 649–651.
7. Campo G., Guastaroba P., Marzocchi A. et al. Impact of COPD on long-term outcome after ST-segment elevation myocardial infarction receiving primary percutaneous coronary intervention. Chest. 2013; 144 (3): 750–757. DOI: 10.1378/chest.12-2313.
8. Feary J.R., Rodrigues L.C., Smith C.J. et al. Prevalence of major comorbidities in subjects with COPD and incidence of myocardial infarction and stroke: a comprehensive analysis using data from primary care. Thorax. 2010; 65 (11): 956–962. DOI: 10.1136/thx.2009.128082.
9. Sethi S. Bacteria in exacerbations of chronic obstructive pulmonary disease: Phenomenon or epiphenomenon? Proc. Am. Thorac. Soc. 2004; 1 (2): 109–114. Available at: https://www.atsjournals.org/doi/pdf/10.1513/pats.2306029
10. Wedzicha J.A. Role of viruses in exacerbations of chronic obstructive pulmonary disease. Proc. Am. Thorac. Soc. 2004; 1 (2): 115–120. DOI: 10.1513/pats.2306030.
11. Wedzicha J.A., Seemungal T.A., MacCallum P.K. et al. Acute exacerbations of chronic obstructive pulmonary disease are accompanied by elevations of plasma fibrinogen and serum IL-6 levels. Thromb. Haemost. 2000; 84 (2): 210–215.
12. Chen Y.W., Leung J.M., Sin D.D. A Systematic review of diagnostic biomarkers of COPD exacerbation. PLoS ONE. 2016; 11 (7): e0158843. DOI: 10.1371/journal.pone.0158843.
13. Smeeth L., Thomas S.L., Hall A.J. et al. Risk of Myocardial infarction and stroke after acute infection or vaccination. N. Engl. J. Med. 2004; 351 (25): 2611–2618. DOI: 10.1056/NEJMoa041747.
14. Donaldson G.C., Hurst J.R., Smith C.J. et al. Increased risk of myocardial infarction and stroke following exacerbation of COPD. Chest. 2010; 137 (5): 1091–1097. DOI: 10.1378/chest.09-2029.
15. Brekke P.H., Omland T., Smith P., Soyseth V. Underdiagnosis of myocardial infarction in COPD-Cardiac Infarction Injury Score (CIIS) in patients hospitalised for COPD exacerbation. Respir. Med. 2008; 102 (9): 1243–1247. DOI: 10.1016/j.rmed.2008.04.010.
16. McAllister D.A., Maclay J.D., Mills N.L. et al. Diagnosis of myocardial infarction following hospitalization for exacerbation of COPD. Eur. Respir. J. 2012; 39 (5): 1097–1103. DOI: 10.1183/09031936.00124811.
17. Kunisaki K.M., Dransfield M.T., Anderson J.A. et al. Exacerbations of chronic obstructive pulmonary disease and cardiac events: A post hoc cohort analysis from the SUMMIT randomized clinical trial. Am. J. Respir. Crit. Care Med. 2018; 198 (1): 51–57. DOI: 10.1164/rccm.201711-2239OC.
18. Rabe K.F., Hurst J.R., Suissa S. Cardiovascular disease and COPD: dangerous liaisons? Eur. Respir. Rev. 2018; 27 (149): pii: 180057. DOI: 10.1183/16000617.0057-2018.
19. Meier C.R., Jick S.S., Derby L.E. et al. Acute respiratory-tract infections and risk of first-time acute myocardial infarction. Lancet. 1998; 351 (9114): 1467–1471. DOI: 10.1016/s0140-6736(97)11084-4.
20. Clayton T.C., Thompson M., Meade T.W. Recent respiratory infection and risk of cardiovascular disease: case-control study through a general practice database. Eur. Heart J. 2008; 29 (1): 96–103. DOI: 10.1093/eurheartj/ehm516.
21. Hill J., Heslop C., Man S.F. et al. Circulating surfactant protein-D and the risk of cardiovascular morbidity and mortality. Eur. Heart J. 2011; 32 (15): 1918–1925. DOI: 10.1093/eurheartj/ehr124.
22. Van Eeden S.F., Sin D.D. Chronic obstructive pulmonary disease: A chronic systemic inflammatory disease. Respiration. 2008; 75 (2): 224–238. Available at: https://www.karger.com/Article/Abstract/111820
23. Danesh J., Wheeler J.G., Hirschfield G.M. et al. C-reactive protein and other circulating markers of inflammation in the prediction of coronary heart disease. N. Engl. J. Med. 2004; 350 (14): 1387–1397. DOI: 10.1056/NEJMoa032804.
24. Vanhaverbeke M., Veltman D., Pattyn N. et al. CRP-reactive protein during and after myocardial infarction in relation to cardiac injury and left ventricular function at follow-up Running head: CRP during and after myocardial infarction. Clin. Cardiol. 2018; 41 (9): 1201–1206. DOI: 10.1002/clc.23017.
25. Maclay J.D., McAllister D.A., Johnston S. et al. Increased platelet activation in patients with stable and acute exacerbation of COPD. Thorax. 2011; 66 (9): 769–774. DOI: 10.1136/thx.2010.157529.
26. Malerba M., Clini E., Malagola M., Avanzi G.C. Platelet activation as a novel mechanism of atherothrombotic risk in chronic obstructive pulmonary disease. Expert. Rev. Hematol. 2013; 6 (4): 475–483. DOI: 10.1586/17474086.2013.814835.
27. Perski A., Olsson G., Landou C. et al. Minimum heart rate and coronary atherosclerosis: independent relations to global severity and rate of progression of angiographic lesions in men with myocardial infarction at a young age. Am. Heart J. 1992; 123 (3): 609–616. DOI: 10.1016/0002-8703(92)90497-j.
28. Heidland U.E., Strauer B.E. Left ventricular muscle mass and elevated heart rate are associated with coronary plaque disruption. Circulation. 2001; 104 (13): 1477–1482. DOI: 10.1161/hc3801.096325.
29. Hoiseth A.D., Omland T., Hagve T.A. et al. Determinants of high-sensitivity cardiac troponin T during acute exacerbation of chronic obstructive pulmonary disease: a prospective cohort study. BMC Pulm. Med. 2012; 12: 22. DOI: 10.1186/1471-2466-12-22.
30. Vlachopoulos C., Aznaouridis K., Stefanadis C. Prediction of cardiovascular event sandall-cause mortality with arterial stiffness: A systematic review and meta-analysis. J. Am. Coll. Cardiol. 2010; 55 (13): 1318–1327. DOI: 10.1016/j.jacc.2009.10.061.
31. Vlachopoulos C., Alexopoulos N., Stefanadis C. Fast in the aorta, slow in the coronaries. Cardiology. 2010; 116 (4): 257–260. DOI: 10.1159/000319599.
32. Patel A.R., Kowlessar B.S., Donaldson G.C. et al. Cardiovascular risk, myocardial injury, and exacerbations of chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 2013; 188 (9): 1091–1099. DOI: 10.1164/rccm.201306-1170OC.
33. Makarova M.A., Avdeev S.N., Chuchalin A.G. [Hypoxemia as a potential risk factor of endothelial dysfunction and arterial stiffness in patients with chronic obstructive pulmonary disease]. Pul'monologiya. 2013; (3): 36–40. DOI: 10.18093/0869-0189-2013-0-3-36-40 (in Russian).
34. Stewart A.G., Waterhouse J.C., Howard P. Cardiovascular autonomic nerve function in patients with hypoxaemic chronic obstructive pulmonary disease. Eur. Respir. J. 1991; 4 (10): 1207–1214.
35. Rothnie K.J., Smeeth L., Herrett E. et al. Closing the mortality gap after a myocardial infarction in people with and without chronic obstructive pulmonary disease. Heart. 2015; 101 (14): 1103–1110. DOI: 10.1136/heartjnl-2014-307251.
36. Thygesen K., Alpert J.S., White H.D. Universal definition of myocardial infarction. J. Am. Coll. Cardiol. 2007; 50 (22): 2173–2195. DOI: 10.1016/j.jacc.2007.09.011.
37. Nordenskjöld A.M., Hammar P., Ahlström H. et al. Unrecognized myocardial infarction assessed by cardiac magnetic resonance imaging is associated with adverse long-term prognosis. PLoS ONE. 2018; 13 (7): e0200381. DOI: 10.1371/journal.pone.0200381.
38. Budoff M.J., Dowe D., Jollis J.G. et al. Diagnostic performance of 64-multidetector row coronary computed tomographic angiography for evaluation of coronary artery stenosis in individuals without known coronary artery disease: results from the prospective multicenter ACCURACY (Assessment by Coronary Computed Tomographic Angiography of Individuals Undergoing Invasive Coronary Angiography) trial. J. Am. Coll. Cardiol. 2008; 52 (21): 1724–1732. DOI: 10.1016/j.jacc.2008.07.031.
39. Budoff M.J., Nasir K., Kinney G.L. et al. Coronary artery and thoracic calcium on non-contrast thoracic CT scans: comparison of ungated and gated examinations in patients from the COPD Gene cohort. J. Cardiovasc. Comput. Tomogr. 2011; 5 (2): 113–118. DOI: 10.1016/j.jcct.2010.11.002.
40. Pavasini R., d’Ascenzo F., Campo G. et al. Cardiac troponin elevation predicts all-cause mortality in patients with acute exacerbation of chronic obstructive pulmonary disease: systematic review and meta-analysis. Int. J. Cardiol. 2015; 191: 187–193. DOI: 10.1016/j.ijcard.2015.05.006.
41. Buchan A., Bennett R., Coad A. et al. The role of cardiac biomarkers for predicting left ventricular dysfunction and cardiovascular mortality in acute exacerbations of COPD. Open Heart. 2015; 2 (1): e000052. DOI: 10.1136/openhrt-2014-000052.
42. Marcun R., Sustic A., Brguljan P.M. et al. Cardiac biomarkers predict outcome after hospitalization for an acute exacerbation of chronic obstructive pulmonary disease. Int. J. Cardiol. 2012; 161 (3): 156–159. DOI: 10.1016/j.ijcard.2012.05.044.
43. Onishi K. Total management of chronic obstructive pulmonary disease (COPD) as an independent risk factor for cardiovascular disease. J. Cardiol. 2017; 70 (2): 128–134. DOI: 10.1016/j.jjcc.2017.03.001.
44. Harrison M.T., Short P., Williamson P.A. et al. Thrombocytosis is associated with increased short and long term mortality after exacerbation of chronic obstructive pulmonary disease: a role for antiplatelet therapy? Thorax. 2014; 69 (7): 609–615. DOI: 10.1136/thoraxjnl-2013-203996.
45. Pavasini R., Biscaglia S., d’Ascenzo F. et al. Antiplatelet treatment reduces all-cause mortality in COPD patients: a systematic review and meta-analysis. COPD. 2016; 13 (4): 509–514. DOI: 10.3109/15412555.2015.1099620.
46. Goto Y., Faridi M.K., Camargo C.A., Hasegawa K. The association of aspirin use with severity of acute exacerbation of chronic obstructive pulmonary disease: a retrospective cohort study. NPJ Prim. Care Respir. Med. 2018; 28 (1): 7. DOI: 10.1038/s41533-018-0074-x.
47. Schwameis R., Pils S., Weber M. et al. Acetylic salicylic acid for the treatment of chronic obstructive pulmonary disease: a randomized, double-blind, placebo-controlled trial. Pharmacology. 2016; 98 (1-2): 93–98. DOI: 10.1159/000446349.
48. Domanski M.J., Krause-Steinrauf H., Massie B.M. et al. A comparative analysis of the results from 4 trials of beta-blocker therapy for heart failure: BEST, CIBIS-II, MERIT-HF, and COPERNICUS. J. Card. Fail. 2003; 9 (5): 354–363.
49. Puente-Maestu L., Calle M., Ortega-González Á. et al. Multicentric study on the beta-blocker use and relation with exacerbations in COPD. Respir. Med. 2014; 108 (5): 737–744. DOI: 10.1016/j.rmed.2014.02.009.
50. Quint J.K., Herrett E., Bhaskaran K. et al. Effect of β blockers on mortality after myocardial infarction in adults with COPD: population based cohort study of UK electronic healthcare records. Br. Med. J. 2013; 347: f6650. DOI: 10.1136/bmj.f6650.
51. Petta V., Perlikos F., Loukides S. et al. Therapeutic effects of the combination of inhaled beta2-agonists and beta-blockers in COPD patients with cardiovascular disease. Heart Fail. Rev. 2017; 22 (6): 753–763. DOI: 10.1007/s10741-017-9646-z.
52. Salpeter S., Ormiston T., Salpeter E. Cardioselective beta-blockers for chronic obstructive pulmonary disease. Cochrane Database Syst. Rev. 2005; (4): CD003566. DOI: 10.1002/14651858.CD003566.pub2.
53. Bhatt S.P., Wells J.M., Kinney G.L. et al. β-blockers are associated with a reduction in COPD exacerbations. Thorax. 2016; 71 (1): 8–14. DOI: 10.1136/thoraxjnl-2015-207251.
54. Rutten F.H., Zuithoff N.P., Hak E. et al. β-blockers may reduce mortality and risk of exacerbations in patients with chronic obstructive pulmonary disease. Arch. Intern. Med. 2010; 170 (10): 880–887. DOI: 10.1001/archinternmed.2010.112.
55. Du Q., Sun Y., Ding N., Chen Y. Beta-blockers reduced the risk of mortality and exacerbation in patients with COPD: a meta-analysis of observational studies. PLoS ONE. 2014; 9 (11): e113048. DOI: 10.1371/journal.pone.0113048.
56. Mortensen E.M., Copeland L.A., Pugh M.J. et al. Impact of statins and ACE inhibitors on mortality after COPD exacerbations. Respir. Res. 2009; 10: 45. DOI: 10.1186/1465-9921-10-45.
57. Criner G.J., Connett J.E., Aaron S.D. et al. Simvastatin for the prevention of exacerbations in moderate-to-severe COPD. N. Engl. J. Med. 2014; 370 (23): 2201–2210. DOI: 10.1056/NEJMoa1403086.
58. Morgan A.D., Zakeri R., Quint J.K. Defining the relationship between COPD and CVD: what are the implications for clinical practice? Ther. Adv. Respir. Dis. 2018; 12: 1753465817750524. DOI: 10.1177/1753465817750524.
59. Wise R.A., Anzueto A., Cotton D. et al. Tiotropium Respimat inhaler and the risk of death in COPD. N. Engl. J. Med. 2013; 369 (16): 1491–1501. DOI: 10.1056/NEJMoa1303342.
60. Lipson D.A., Barnhart F., Brealey N. et al. Once-daily single-inhaler triple versus dual therapy in patients with COPD. N. Engl. J. Med. 2018; 378 (18): 1671–1680. DOI: 10.1056/NEJMoa1713901.
61. Wang M.T., Liou J.T., Lin C.W. et al. Association of cardiovascular risk with inhaled long-acting bronchodilators in patients with chronic obstructive pulmonary disease: a nested case-control study. JAMA Intern. Med. 2018; 178 (2): 229–238. DOI: 10.1001/jamainternmed.2017.7720.
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Anaev E.Kh., Gorelik I.L. Acute exacerbation of COPD and comorbid cardiovascular diseases. PULMONOLOGIYA. 2019;29(4):468-476. (In Russ.) https://doi.org/10.18093/0869-0189-2019-29-4-468-476
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