Evaluation of a role of cytokine gene polymorphisms in development of bronchial asthma in the Republic of Bashkortostan
https://doi.org/10.18093/0869-0189-2012-0-5-37-40
Abstract
Summary. Asthma is one of the most common, severe and debilitating multifactorial diseases resulting from complex interaction between genes and environ mental factors. The aim of the present work was to analyze the association between cytokine gene polymorphisms and development of asthma in population of the Republic of Bashkortostan. A total of 638 patients with asthma and 366 healthy individuals were recruited in our investigation. In summary, the study of cytokine gene polymorphisms and genegene interaction suggested an important role of TNFA, IL4, CCL11 and IL13 genepolymorphisms in the development of asthma in Bashkortostan population.
About the Authors
A. S. Karunas
ФГБУ науки "Институт биохимии и генетики Уфимского научного центра РАН"
Russian Federation
Russian Federation
Yu. Yu. Fedorova
ФГБУ науки "Институт биохимии и генетики Уфимского научного центра РАН"
Russian Federation
Russian Federation
N. N. Ramazanova
ГБОУ ВПО "Башкирский государственный медицинский университет" Минздравсоцразвития России
Russian Federation
Russian Federation
E. S. Galimova
ГБОУ ВПО "Башкирский государственный медицинский университет" Минздравсоцразвития России
Russian Federation
Russian Federation
G. F. Gimalova
ФГБУ науки "Институт биохимии и генетики Уфимского научного центра РАН"
Russian Federation
Russian Federation
L. L. Guryeva
ГБОУ ВПО "Башкирский государственный медицинский университет" Минздравсоцразвития России
Russian Federation
Russian Federation
S. V. Levasheva
ГБОУ ВПО "Башкирский государственный медицинский университет" Минздравсоцразвития России
Russian Federation
Russian Federation
A. R. Biktasheva
ГБОУ ВПО "Башкирский государственный медицинский университет" Минздравсоцразвития России
Russian Federation
Russian Federation
L. A. Mukhtarova
ГБОУ ВПО "Башкирский государственный медицинский университет" Минздравсоцразвития России
Russian Federation
Russian Federation
Sh. Z. Zagidullin
ГБОУ ВПО "Башкирский государственный медицинский университет" Минздравсоцразвития России
Russian Federation
Russian Federation
E. I. Etkina
ГБОУ ВПО "Башкирский государственный медицинский университет" Минздравсоцразвития России
Russian Federation
Russian Federation
E. K. Khusnutdinova
ФГБУ науки "Институт биохимии и генетики Уфимского научного центра РАН"; ГБОУ ВПО "Башкирский государственный университет"
Russian Federation
Russian Federation
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Review
For citations:
Karunas A.S., Fedorova Yu.Yu., Ramazanova N.N., Galimova E.S., Gimalova G.F., Guryeva L.L., Levasheva S.V., Biktasheva A.R., Mukhtarova L.A., Zagidullin Sh.Z., Etkina E.I., Khusnutdinova E.K. Evaluation of a role of cytokine gene polymorphisms in development of bronchial asthma in the Republic of Bashkortostan. PULMONOLOGIYA. 2012;(5):37-40. (In Russ.) https://doi.org/10.18093/0869-0189-2012-0-5-37-40
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