Bronchial asthma and respiratory system disorders as an "asthma-plus" syndrome
https://doi.org/10.18093/0869-0189-2018-28-6-722-729
Abstract
Comorbidity in asthma encompasses different respiratory system disorders including dysfunctional breathing and vocal cord dysfunction. Such comorbidity is referred to as "asthma-plus" syndrome. This condition is not fully investigated resulting in its late diagnosis and inadequate treatment. This article is a review of clinical signs, differential diagnosis, and key issues of management of "asthma-plus" syndrome.
About the Author
V. N. Abrosimov
Federal State Budgetary Educational Institution of Higher Professional Education Ryazan State Medical University named after academician I.P.Pavlov of the Ministry of Health of the Russian Federation
Russian Federation
Competing Interests:
Russian Federation
Vladimir N. Abrosimov – Doctor of Medicine, Professor, Head of Chair of Therapy and Family Medicine with a Course of Medical and Social Expertise, Department of Additional Professional Education.
Ul. Vysokovoltnaya 9, Ryazan, 390026, tel.: (4912) 96-27-93
Competing Interests:
No conflict of interest
References
1. Hull J.H., Walsted E.S., Backer V. et al. The asthma-plus syndrome. Exp. Rev. Respir. Med. 2017; 11 (7): 513–515. DOI: 10.1080/17476348.2017.1335602.
2. Chuchalin A.G., Aisanov Z.R., Belevskiy A.S. et al. Russian Respiratory Society. Federal clinical guidelines for the diagnosis and treatment of bronchial asthma. 2016. Available at: http://spulmo.ru/download/Asthmarec3.pdf (in Russian).
3. GINA 2016. Global Initiative for Asthma. Global Strategy for Asthma Management and Prevention. Updated 2016. Available at: https://ginasthma.org/wp-content/uploads/2016/04/GINA-Appendix-2016-final.pdf
4. Porsbjerg C., Ulrik C., Skjold T. et al. Nordic consensus statement on the systematic assessment and management of possible severe asthma in adults. Eur. Clin. Respir. J. 2018; 5 (1): 1440868. DOI: 10.1080/20018525.2018.1440868.
5. Low K., Lau K.K., Holmes P. et al. Abnormal vocal cord function in difficult-to-treat asthma. Am. J. Respir. Crit. Care Med. 2011; 184 (1): 50–56. DOI: 10.1164/rccm.201010-1604OC.
6. Balkissoon R., Kenn K. Asthma: vocal cord dysfunction (VCD) and other dysfunctional breathing disorders. Semin. Respir. Crit. Care Med. 2012; 33 (6): 595–605. DOI: 10.1055/s-0032-1326959.
7. Boulet L.P., Boulay M.E. Asthma-related comorbidities. Exp. Rev. Respir. Med. 2011; 5 (3): 377–393. DOI: 10.1586/ers.11.34.
8. Porsbjerg C., Menzies-Gow A. Co-morbidities in severe asthma: clinical impact and management. Respirology. 2017; 22 (4): 651–661. DOI: 10.1111/resp.13026.
9. Abrosimov V.N. Bronchial asthma: hyperventilation and hyperventilation syndrome. In.: Chuchalin A.G., ed. Bronchial asthma. M.: Agar; 1997. Vol. 2: 3–39 (in Russian).
10. Thomas M., McKinley R.K., Freeman E. et al. The prevalence of dysfunctional breathing in adults in the community with and without asthma. Prim. Care Respir. J. 2005; 14 (2): 78–82. DOI: 10.1016/j.pcrj.2004.10.007.
11. Prys-Picard C.O., Kellett F., Niven R.M. Disproportionate breathlessness associated with deep sighing breathing in a patient presenting with difficult-to-treat asthma. Chest. 2006; 130 (6): 1723–1725. DOI: 10.1378/chest.130.6.1723.
12. Van Dixhoorn J. Hyperventilation and dysfunctional breathing. Biol. Psychol. 1997; (46): 90–91.
13. Folgering H. The pathophysiology of hyperventilation syndrome. Monaldi Arch. Chest Dis. 1999; 54 (4): 365–371.
14. Van Dixhoorn J., Folgering H. The Nijmegen Questionnaire and dysfunctional breathing. ERJ Open Res. 2015; 1 (1): 00001–2015. DOI: 10.1183/23120541.00001-2015.
15. Robson A. Dyspnoea, hyperventilation and functional cough: a guide to which tests help sort them out. Breathe (Sheff). 2017; 13 (1): 45–50. DOI: 10.1183/20734735.019716.
16. Ritz T., Rosenfield D., Steele A.M. et al. Controlling asthma by training of Capnometry-Assisted Hypoventilation (CATCH) vs slow breathing: a randomized controlled trial. Chest. 2014; 146 (5): 1237–1247. DOI: 10.1378/chest.14-0665.
17. Agache I., Ciobanu C., Paul G., Rogozea L. Dysfunctional breathing phenotype in adults with asthma – incidence and risk factors. Clin. Transl. Allergy. 2012; 2 (1): 18. DOI: 10.1186/2045-7022-2-18.
18. Brussino L., Solidoro P., Rolla G. Is it severe asthma or asthma with severe comorbidities? J. Asthma Allergy. 2017; (10): 303–305. DOI: 10.2147/JAA.S150462.
19. Rakita D.R., Kuspanalieva D.S. Effect of hyperventilation syndrome on the quality of life of patients with bronchial asthma. Rossyskiy mediko-biologicheskiy vestnik imeni akademika I.P.Pavlova. 2012; (1): 86–87 (in Russian).
20. Veidal S., Jeppegaard M., Sverrild A. et al. The impact of dysfunctional breathing on the assessment of asthma control. Respir. Med. 2017; (123): 42–47. DOI: 10.1016/j.rmed.2016.12.008.
21. Boulding R., Stacey R., Niven R., Fowler S.J. Dysfunctional breathing: a review of the literature and proposal for classification. Eur. Respir. Rev. 2016; 25 (141): 287–294. DOI: 10.1183/16000617.0088-2015.
22. de Groot E.P., Duiverman E.J., Brand P.L. Dysfunctional breathing in children with asthma: a rare but relevant comorbidity. Eur. Respir J. 2013; 41 (5): 1068–1073. DOI: 10.1183/09031936.00130212.
23. Bruton A., Lee A., Yardley L. et al. Physiotherapy breathing retraining for asthma: a randomised controlled trial. Lancet Respir. Med. 2018; 6 (1): 19–28. DOI: 10.1016/S2213-2600(17)30474-5.
24. Weinberger M., Doshi D. Vocal cord dysfunction: a functional cause of respiratory distress. Breathe (Sheff). 2017; 13 (1): 15–21. DOI: 10.1183/20734735.019316.
25. Brugman S. The many faces of vocal cord dysfunction: what 36 years of literature tell us. Am. J. Respir. Crit. Care Med. 2003; 167 (7): A588.
26. Christopher K.L., Wood R.P., Eckert R.C. et al. Vocal-cord dysfunction presenting as asthma. N. Engl. J. Med. 1983; 308 (26): 1566–1570. DOI: 10.1056/NEJM198306303082605.
27. Traister R.S., Fajt M.L., Petrov A.A. The morbidity and cost of vocal cord dysfunction misdiagnosed as asthma. Allergy Asthma Proc. 2016; 37 (2): 25–31. DOI: 10.2500/aap.2016.37.3936.
28. Fretzayas А., Moustaki М., Loukou I., Douros K. Differentiating vocal cord dysfunction from asthma. J. Asthma Allergy. 2017; (10): 277–283. DOI: 10.2147/JAA.S146007.
29. Morris M.J., Allan P.F., Perkins P.J. Vocal cord dysfunction, etiologies and treatment. Clin. Pulm. Med, 2006; 13 (2): 73–86. DOI: 10.1097/01.cpm.0000203745.50250.3b.
30. Traister R.S., Fajt M.L., Whitman-Purves E. et al. A retrospective analysis comparing subjects with isolated and co-existent vocal cord dysfunction and asthma. Allergy Asthma Proc. 2013; 34 (4): 349–355. DOI: 10.2500/aap.2013.34.3673.
31. Ibrahim W.H., Gheriani H.A., Almohamed A.A., Raza T. Paradoxical vocal cord motion disorder: past, present and future. Postgrad Med. J. 2007; 83 (977): 164–172. DOI: 10.1136/pgmj.2006.052522.
32. Idrees M., FitzGerald J.M. Vocal cord dysfunction in bronchial asthma. A review article. J. Asthma. 2015; 52 (4): 327–335. DOI: 10.3109/02770903.2014.982288.
33. Bisdorff B., Kenn K., Nowak D. et al. Asthma and vocal cord dysfunction related symptoms in the general population – a pilot study. Ann. Allergy Asthma Immunol. 2014; 113 (5): 576–577. DOI: 10.1016/j.anai.2014.08.009.
34. Ng T.T. The forgotten cause of stridor in the emergency department. Open Access Emerg. Med. 2017; 9: 19–22. DOI: 10.2147/OAEM.S125593.
35. Kann K., Long B., Koyfman A. Clinical mimics: an emergency medicine-focused review of asthma mimics. J. Emerg. Med. 2017; 53 (2): 195–201. DOI: 10.1016/j.jemermed.2017.01.005.
36. Truong A., Truong D.T. Vocal cord dysfunction: An updated review. Otolaryngology: Open Access. 2011; S1: 002. DOI: 10.4172/2161-119X.S1-002.
37. Morris M.J., Christopher K.L. Diagnostic criteria for the classification of vocal cord dysfunction. Chest. 2010; 138 (5): 1213–1223. DOI: 10.1378/chest.09-2944.
38. Traister R.S., Fajt M.L., Whitman-Purves E. et al. A retrospective analysis comparing subjects with isolated and co-existent vocalcord dysfunction and asthma. Allergy Asthma Proc. 2013; 34 (4): 349–355. DOI: 10.2500/aap.2013.34.3673.
39. Kaminsky D.A. "All that wheezes is not asthma" (or COPD)! Сhest. 2015; 147 (2): 284–286. DOI: 10.1378/chest.14-1813.
40. Petrov Yu.V., Glotov S.I., Abrosimov V.N. The first experience of intrapulmonary electronic auscultation in patients with chronic obstructive pulmonary disease and bronchial asthma. Nauka molodykh (Eruditio Juvenium). 2015; (4): 45–49 (in Russian).
41. Randhawa I., Nussbaum E. Images in clinical medicine. Not all that wheezes is bronchial asthma. N. Engl. J. Med. 2010; 363 (1): e1. DOI: 10.1056/NEJMicm0906105.
42. Amimoto Y., Nakano H., Masumoto N. Lung sound analysis in a patient with vocal cord dysfunction and bronchial asthma. J. Asthma. 2012; 49 (3): 227–229. DOI: 10.3109/02770903.2012.656867.
43. Sandage M.J., Zelazny S.K. Paradoxical vocal fold motion in children and adolescents. Lang. Speech Hear. Serv. Sch. 2004; 35 (4): 353–362. DOI: 10.1044/0161-1461(2004/034).
44. Liyanagedera S., McLeod R., Elhassan H.A. Exercise induced laryngeal obstruction: a review of diagnosis and management. Eur. Arch. Otorhinolaryngol. 2017; 274 (4): 1781–1789. DOI: 10.1007/s00405-016-4338-1.
45. Johansson H., Norlander K., Berglund L. et al. Prevalence of exercise-induced bronchoconstriction and exercise-induced laryngeal obstruction in a general adolescent population. Thorax. 2015; 70 (1): 57–63. DOI: 10.1136/thoraxjnl-2014-205738.
46. Buchvald F., Phillipsen L.D., Hjuler T., Nielsen K.G. Exercise-induced inspiratory symptoms in school children. Pediatr. Pulmonol. 2016; 51 (11): 1200–1205. DOI: 10.1002/ppul.23530.
47. Hseu A., Sandler M., Ericson D. et al. Paradoxical vocal fold motion in children presenting with exercise induced dyspnea. Int. J. Pediatr. Otorhinolaryngol. 2016; (90): 165–169. DOI: 10.1016/j.ijporl.2016.09.007.
48. Forrest L.A., Husein T., Husein O. Paradoxical vocal cord motion: classification and treatment. Laryngoscope. 2012; 122 (4): 844–853. DOI: 10.1002/lary.23176.
49. Christopher K.L., Morris M.J. Vocal cord dysfunction, paradoxic vocal fold motion, or laryngomalacia? Our understanding requires an interdisciplinary approach. Otolaryngol. Clin. North. Am. 2010; 43 (1): 43–66. DOI: 10.1016/j.otc.2009.12.002.
50. Maschka D.A., Bauman N.M., McCray P.B. Jr et al. A classification scheme for paradoxical vocal cord motion. Laryngoscope. 1997; 107 (11, Pt 1): 1429–1435.
51. Mirza К.К., Walsted Е.S., Backer V. Ergospirometry with concurrent fibre optic laryngoscopy: a randomised crossover study. Eur. Clin. Respir. J. 2017; 4 (1): 1399033. DOI: 10.1080/20018525.2017.1399033.
52. Chiang T., Marcinow A.M., de Silva B.W. et al. Exercise-induced paradoxical vocal fold motion disorder: diagnosis and management. Laryngoscope. 2013; 123 (3): 727–731. DOI: 10.1002/lary.23654.
53. Hull J.H., Ansley L., Price O.J. et al. Eucapnic voluntary hyperpnea: gold standard for diagnosing exercise-Induced bronchoconstriction in athletes? Sports Med. 2016; 46 (8): 1083–1093. DOI: 10.1007/s40279-016-0491-3.
54. Gimenez L.M., Zafra H. Vocal cord dysfunction: an update. Ann. Allergy Asthma Immunol. 2011; 106 (4): 267–274. DOI: 10.1016/j.anai.2010.09.004.
55. Komarow H.D., Young M., Nelson C., Metcalfe D.D. Vocal cord dysfunction as demonstrated by impulse oscillometry. J. Allergy Clin. Immunol. Pract. 2013; 1 (4): 387–393. DOI: 10.1016/j.jaip.2013.05.005.
56. Fowler S.J., Thurston A., Chesworth B. et al. The VCDQ – a questionnaire for symptom monitoring in vocal cord dysfunction. Clin. Exp. Allergy. 2015; 45 (9): 1406–1411. DOI: 10.1111/cea.12550.
57. Traister R.S., Fajt M.L., Landsittel D., Petrov A.A. A novel scoring system to distinguish vocal cord dysfunction from asthma. J. Allergy Clin. Immunol. Pract. 2014; 2 (1): 65–69. DOI: 10.1016/j.jaip.2013.09.002.
58. Patel R.R., Venediktov R., Schooling T., Wang B. Evidence-based systematic review: Effects of speech-language pathology treatment for Individuals with paradoxical vocal fold motion. Am. J. Speech Lang. Pathol. 2015; 24 (3): 566–584. DOI: 10.1044/2015_AJSLP-14-0120.
59. Kenn K., Balkissoon R. Vocal cord dysfunction: what do we know? Eur. Respir. J. 2011; 37 (1): 194–200. DOI: 10.1183/09031936.00192809.
60. Hemph A.B., Jakobsson J.G. Helium-oxygen mixture for treatment in upper airway obstruction; a mini-review. J. Acute Med. 2016; 6 (4): 77–81. DOI: 10.1016/j.jacme.2016.08.006.
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For citations:
Abrosimov V.N. Bronchial asthma and respiratory system disorders as an "asthma-plus" syndrome. PULMONOLOGIYA. 2018;28(6):722-729. (In Russ.) https://doi.org/10.18093/0869-0189-2018-28-6-722-729
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