An informative value of impulse oscillonetry for detecting restrictive abnormalities in idiopathic pulmonary fibrosis

The aim of this study was to investigate a role of impulse oscillometry (IO) for diagnosis of restrictive abnormalities in patients with idiopathic pulmonary fibrosis (IPF). Methods. Seventy two patients with restrictive ventilatory disorders diagnosed with spirometry and body plethysmography were involved in the study. The patients were divided into two groups: the group 1 (n = 34) comprised IPF patients, the group 2 (n = 38) comprised patients with respiratory diseases without extended pulmonary fibrosis. Data of spirometry, body plethysmography, lung diffusion test, and IO were analyzed. Results. IO was the most informative method for diagnosis of restrictive abnormalities in IPF patients: abnormal values, predominantly deltaXrs5, were found in 68% of the patients. IO was less useful in patients with non-fibrotic respiratory diseases where abnormal basic IO values were found in 39% of the patients. Decreased Xrs5, increased fres, unchanged Rrs5 and Rrs20, and abnormal absolute frequency dependence of Rrs were found in IPF patients with restrictive abnormalities; these changes could be seen in any respiratory disease with TLC ≤ 69%pred. Moreover, abnormal relative frequency dependence of Rrs (D(Rrs5–Rrs20)/Rrs20%) was detected. Conclusion. IO could be used as additional method for detecting restrictive abnormalities in patients with significant fibrotic lesions of the lungs.

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