Vilanterol / umeclidinium bromide combination as a basic therapy for chronic obstructive pulmonary disease
https://doi.org/10.18093/0869-0189-2016-26-1-79-84
Abstract
A review of published data on clinical efficacy and safety of a new vilanterol/umeclidinium bromide fixed combination in comparison with its separate components and with other long-acting bronchodilators has been performed in this article. Several randomized controlled large trials demonstrated a higher improvement in the airflow limitation and lung hyperinflation under the treatment with the fixed combination of vilanterol and umeclidinium bromide compared to monotherapy with umeclidinium bromide or vilanterol or tiotropium bromide. Vilanterol/umeclidinium bromide fixed combination also improved exertional dyspnea, quality of life and exercise endurance time in stable patients with moderate to severe or very severe chronic obstructive pulmonary disease (COPD). Good tolerability of the drug was noted in all the studies. Vilanterol/umeclidinium bromide fixed combination is delivered via Ellipta dry powder inhaler which was assessed by most patients as a convenient and easy to use inhaler.
The published data confirmed higher clinical efficacy of dual bronchodilator therapy in patients with COPD of categories B, C and D.
About the Author
S. Yu. Chikina
Federal Pulmonology Research Institute, Federal Medical and Biological Agency of Russia: 32, build. 4, 11th Parkovaya str., Moscow, 105077, Russia
Russian Federation
Russian Federation
PhD, Senior Researcher at Laboratory of Functional and Ultra-sound Investigations; Federal Institution «Pulmonology Research Institute», Federal Medical and Biological Agency of Russia; tel.: (495) 967-77-44;
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Review
For citations:
Chikina S.Yu. Vilanterol / umeclidinium bromide combination as a basic therapy for chronic obstructive pulmonary disease. PULMONOLOGIYA. 2016;26(1):79-84. (In Russ.) https://doi.org/10.18093/0869-0189-2016-26-1-79-84
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2016
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