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Potential of hexapeptide succinate in the pharmacotherapy of respiratory diseases: resolution of the Board of Experts

https://doi.org/10.18093/0869-0189-2026-36-3-538-545

Abstract

The expansion of available treatment methods for community-acquired pneumonia (CAP) is more relevant than ever. Drugs with pronounced anti-inflammatory, antioxidant, and regenerating properties are needed to help prevent lung damage and minimize potential complications as part of complex therapy. The purpose of the publication of the resolution of the Board of Experts was to discuss the efficacy and safety of hexapeptide succinate (Amberwin® Pulmo) in the treatment of respiratory diseases, primarily CAP. The Board of Experts met on February 26, 2026 in Moscow under the chairmanship of the Doctor of Medicine, Professor, Academician of Russian Academy of Sciences S.N.Avdeev. Results. Phase III clinical trials demonstrated the following advantages of hexapeptide succinate: anti-inflammatory, immunoregulatory, antioxidant, reparative and organoprotective effects; rapid reduction in the level of pro-inflammatory cytokines, acceleration of clinical effect, reduction of hospitalization time, and cost-effectiveness. Conclusion. The data presented justify the inclusion of hexapeptide succinate in clinical guidelines for the treatment of CAP in adults.

About the Authors

S. N. Avdeev
Federal State Autonomous Educational Institution of Higher Education I.M.Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University)
Russian Federation

Sergey N. Avdeev, Doctor of Medicine, Professor, Academician of Russian Academy of Sciences, Director of the National Medical Research Center for Pulmonology; Head of the Department of Pulmonology, N.V.Sklifosovsky Institute of Clinical Medicine, Federal State Autonomous Educational Institution of Higher Education I.M.Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University); Chief Pulmonologist of the Ministry of Health of the Russian Federation

ul. Trubetskaya 8, build. 2, Moscow, 119991

SciProfiles: 741582;

Scopus Author ID: 7003292838


V. N. Antonov
Federal State Budgetary Educational Institution of Higher Education “South-Ural State Medical University” of the Ministry of Healthcare of the Russian Federation
Russian Federation

Vladimir N. Antonov, Doctor of Medicine, Professor, Department of Therapy, Institute of Additional Professional Education, Chief Researcher, Institute of Pulmonology

ul. Vorovskogo 64, Chelyabinsk, 454092


A. A. Vizel
Federal State Budgetary Educational Institution of Higher Education Kazan State Medical University of the Ministry of Health of the Russian Federation
Russian Federation

Aleksandr A. Vizel, Doctor of Medicine, Professor, Head of Department of Phthisiology and Pulmonology

ul. Butlerova 49, Kazan, 420012, Republic of Tatarstan

Author ID: 195447


N. S. Gyrgeshkinova
State Budgetary Healthcare Institution “Republican Clinical Infectious Diseases Hospital”, Healthcare Ministry of the Republic of Bashkortostan
Russian Federation

Nadezhda S. Gyrgeshkinova, Deputy Chief Physician for Clinical and Expert Work

ul. Zapototskogo 37, Ufa, 450015, Republic of Bashkortostan


I. V. Demko
Federal State Budgetary Educational Institution of Higher Education “Krasnoyarsk State Medical University named after Professor V.F.Voyno-Yasenetsky” of the Ministry of Health of the Russian Federation
Russian Federation

Irina V. Demko, Doctor of Medicine, Professor, Head of the Department of Hospital Therapy and Immunology with Postgraduate Physician Training Course

ul. Partizana Zheleznyaka 1, Krasnoyarsk, 660022

Author ID: 608300; Researcher ID: O-9740-2015


M. F. Kinyaikin
Federal State Budgetary Educational Institution of Higher Education Tver State Medical University of the Ministry of Health of the Russian Federation; State Budgetary Healthcare Institution “Primorsky Regional Clinical Hospital No.1”
Russian Federation

Mihail F. Kiniaikin, Candidate of Medicine, Associate Professor, Institute of Therapy and Instrumental Diagnostics, Federal State Budget Educational Institution of Higher Education “Pacific State Medical University”, Health care Ministry of Russia; Head of the Regional Pulmonary Center, State Budgetary Healthcare Institution “Primorsky Regional Clinical Hospital No.1”

Primorskiy kray, Vladivostok, prosp. Ostryakova 2, 690002, 

ul. Aleutskaya 57, Primorskiy kray, Vladivostok, 690091


L. S. Kozyreva
Federal State Budgetary Educational Institution of Higher Education “Bashkir State Medical University”, Ministry of Healthcare of Russian Federation
Russian Federation

Liliya S. Kozyreva, Candidate of Medicine, Associate Professor, Department of Therapy and General Medical Practice with a Geriatrics Course, Institute of Additional Professional Education, Head of the Department of Pulmonology at the Clinic, Federal State Budgetary Educational Institution of Higher Education “Bashkir State Medical University”, Ministry of Healthcare of Russian Federation; Chief Freelance Pulmonologist, Ministry of Health of the Republic of Bashkortostan

ul. Lenina 3, Ufa, 450000, Republic of Bashkortostan


N. E. Kostina
Budgetary healthcare institution of the Voronezh region “Voronezh Regional Clinical Hospital No.1”, Ministry of Health of the Voronezh region
Russian Federation

Natalia E. Kostina, Candidate of Medicine, Head of the Pulmonology Department

Moskovskiy prosp. 151, Voronezh, 394066


Z. M. Merzhoeva
Federal State Autonomous Educational Institution of Higher Education I.M.Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University)
Russian Federation

Zamira M. Merzhoeva, Candidate of Medicine, Head of the Department for Analysis of Personnel Policy and Monitoring of the Organization of Medical Care, National Medical Research Center for Pulmonology, Associate Professor, Department of Pulmonology, N.V. Sklifosovsky Institute of Clinical Medicine

ul. Trubetskaya 8, build. 2, Moscow, 119991


O. A. Meshcheryakova
State Autonomous Healthcare Institution “Novokuznetsk City Clinical Hospital No.1 named after G.P.Kurbatov”, Healthcare Ministry of Kuzbass; State Autonomous Healthcare Institution “Kemerovo Clinical District Hospital named after B.V.Batievskiy”, Healthcare Ministry of Kuzbass
Russian Federation

Olga A. Meshcheryakova, Candidate of Medicine, Head of the Pulmonology Department, State Autonomous Healthcare Institution “Novokuznetsk City Clinical Hospital No.1 named after G.P.Kurbatov”, Healthcare Ministry of Kuzbass; Deputy Chief Physician for Medical Affairs, State Autonomous Healthcare Institution “Kemerovo Clinical District Hospital named after B.V.Batievskiy”, Healthcare Ministry of Kuzbass; Chief Pulmonologist of the Kuzbass Healthcare Committee for the Kemerovo Region

prosp. Bardina 28, Novokuznetsk, 654057, 

prosp. Shakhterov 113, Kemerovo, 650002


N. G. Mirtskhulava
State Budgetary Healthcare Institution “Regional Clinical Hospital No.2”, Healthcare Ministry of Krasnodar region
Russian Federation

Nona G. Mirtskhulava, Candidate of Medicine, Pulmonologist, Head of the Pulmonology Department

Krasnyh Partizan 6, buld. 2, Krasnodar, 350012


G. I. Mokhovikov
State Budgetary Healthcare Institution of the Republic of Karelia “V.A.Baranov Republican Hospital”, Healthсare Ministry of Republic of Karelia
Russian Federation

Gennady I. Mokhovikov, Head of Pulmonology Department

ul. Pirogova 3, Petrozavodsk, 185019


D. V. Petrova
Regional State Budgetary Healthcare Institution “Regional Clinical Hospital”, Healthсare Ministry of the Altai Territory
Russian Federation

Dina V. Petrova, Candidate of Medicine, Pulmonologist, Head of the Pulmonology Department

ul. Lyapidevskogo 1, Barnaul, 656045, Altayskiy kray


L. V. Povalyaeva
Federal State Budgetary Educational Institution of Higher Education “Samara State Medical University” of the Ministry of Healthcare of the Russian Federation; State Budgetary Healthcare Institution of the Samara Region “Samara City Hospital No.4”
Russian Federation

Lyudmila V. Povalyaeva, Candidate of Medicine, Associate Professor of the Department of Phthisiology and Pulmonology, Federal State Budgetary Educational Institution of Higher Education “Samara State Medical University” of the Ministry of Healthcare of the Russian Federation; Deputy Chief Physician for Medical Affairs, State Budgetary Healthcare Institution of the Samara Region “Samara City Hospital No.4”

ul. Chapaevskaya 89, Samara, 443099,

ul. Michurina 125, Samara, 443056


O. Y. Pozdnyakova
Federal State Autonomous Educational Institution of Higher Education “North Caucasus Federal University”, Ministry of Science and Higher Education of the Russian Federation
Russian Federation

Oksana Y. Pozdnyakova, Doctor of Medicine, Professor, Department of Clinical Pharmacology with a Course of Additional Professional Education, Federal State Autonomous Educational Institution of Higher Education “North Caucasus Federal University”, Ministry of Science and Higher Education of the Russian Federation; Chief Pulmonologist of the Ministry of Health of the Stavropol Territory, Chief Specialist in General Medical Practice of the North Caucasus Federal District

ul. Pushkina 1A, buld. 20, Stavropol, 355017


S. V. Simonaityte
State Healthcare Institution “Lipetsk Regional Clinical Hospital”, Healthсare Ministry of the Lipetsk Region
Russian Federation

Svetlana V. Simonaites, Candidate of Medicine, Head of the Pulmonology Department

ul. Moskovskaya 6A, Lipetsk, 398042


A. V. Teteneva
Federal State Funded Educational Institution of Higher Education “Siberian State Medical University” of the Ministry of Health of the Russian Federation; Regional State Budgetary Healthcare Institution “Medical and Sanitary Unit No.2”, Tomsk Region Healthcare Department:
Russian Federation

Anna V. Teteneva, Doctor of Medicine, Professor, Department of Internal Medicine Propaedeutics with a course of therapy of the Pediatric Faculty, Federal State Funded Educational Institution of Higher Education “Siberian State Medical University” of the Ministry of Health of the Russian Federation; Deputy Chief Physician for clinical and expert work, Regional State Budgetary Healthcare Institution “Medical and Sanitary Unit No.2”, Tomsk Region Healthcare Department

Moskovskiy trakt 2, Tomsk, 634050, 

ul. Bely  Kuna  3,  Tomsk,  634040


I. N. Trofimenko
Irkutsk State Medical Academy of Postgraduate Education – Branch Campus of the Federal State Budgetary Educational Institution of Further Professional Education “Russian Medical Academy of Continuing Professional Education”, Healthcare Ministry of the Russian Federation
Russian Federation

Irina N. Trofimenko, Doctor of Medicine, Assistant Professor, Head of Department of Clinical Allergology and Pulmonology

mkr Yubilejnyy 100, Irkutsk, 664079

Author ID: 636656


V. D. Fedotov
Federal State Budgetary Educational Institution of Higher Education “Privolzhsky Research Medical University”, Ministry of Healthcare of the Russian Federation; Federal Budgetary Institution of Science “Nizhny Novgorod Scientific Research Institute of Hygiene and Occupational Pathology”, Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing
Russian Federation

Vasily D. Fedotov, Candidate of Medicine, Associate Professor, Department of Therapy and General Medical Practice, Federal State Budgetary Educational Institution of Higher Education “Privolzhsky Research Medical University” of the Ministry of Health of the Russian Federation, Senior Researcher, Clinical Department, Federal Budgetary Scientific Institution “Nizhny Novgorod Scientific Research Institute of Hygiene and Occupational Pathology” of the Federal Service for Supervision of Consumer Rights Protection and Human Wellbeing; Chief Freelance Pulmonologist of the Ministry of Health of the Nizhny Novgorod Region; Chairman of the Nizhny Novgorod Regional Branch of the Russian Respiratory Society

pl. Minina i Pozharskogo10/1, Nizhniy Novgorod, 603950, 

ul. Semashko 20, Nizhniy Novgorod, 603105


N. A. Tsareva
Federal State Autonomous Educational Institution of Higher Education I.M.Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University); Federal State Budgetary Institution “Pulmonology Scientific Research Institute” under Federal Medical and Biological Agency of Russian Federation
Russian Federation

Natalya A. Tsareva, Candidate of Medicine, Associate Professor, Department of Pulmonology, N.V.Sklifosovsky Institute of Clinical Medicine, Federal State Autonomous Educational Institution of Higher Education I.M.Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University); Head of the Intensive Care and Respiratory Failure Laboratory, Federal State Budgetary Institution “Pulmonology Scientific Research Institute” under Federal Medical and Biological Agency of Russian Federation

ul. Trubetskaya 8, build. 2, Moscow, 119991,

Orekhovyy bul’var 28, build. 10, Moscow, 115682


V. V. Tsoma
Federal State Budgetary Educational Institution of Higher Education “Volgograd State Medical University”, Ministry of Healthcare of the Russian Federation; 26 State Budgetary Healthcare Institution “Volgograd Regional Clinical Hospital No.1”, Healthcare Committee of the Volgograd Region
Russian Federation

Vera V. Tsoma, Candidate of Medicine, Associate Professor, Department of Internal Diseases, Institute of Continuing Medical and Pharmaceutical Education, Federal State Budgetary Educational Institution of Higher Education “Volgograd State Medical University”, Ministry of Healthcare of the Russian Federation; Pulmonologist, Consultative Outpatient Clinic, State Budgetary Healthcare Institution “Volgograd Regional Clinical Hospital No.1”, Healthcare Committee of the Volgograd Region; Chief Consultant Pulmonologist of the Volgograd Region Health Committee

pl. Pavshikh Bortsov 1, Volgograd, 400066, 

ul. Angarskaya 13, Volgograd, 400081


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Review

For citations:

Avdeev S.N., Antonov V.N., Vizel A.A., Gyrgeshkinova N.S., Demko I.V., Kinyaikin M.F., Kozyreva L.S., Kostina N.E., Merzhoeva Z.M., Meshcheryakova O.A., Mirtskhulava N.G., Mokhovikov G.I., Petrova D.V., Povalyaeva L.V., Pozdnyakova O.Y., Simonaityte S.V., Teteneva A.V., Trofimenko I.N., Fedotov V.D., Tsareva N.A., Tsoma V.V. Potential of hexapeptide succinate in the pharmacotherapy of respiratory diseases: resolution of the Board of Experts. PULMONOLOGIYA. 2026;36(3):538-545. (In Russ.) https://doi.org/10.18093/0869-0189-2026-36-3-538-545

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