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Drug-induced sarcoidosis-like syndrome associated with anti-IL-4, -13 inhibitor therapy in a patient with T2-associated comorbidities: clinical case

https://doi.org/10.18093/0869-0189-2026-36-3-522-531

Abstract

Expanding the range of biological drugs for the treatment of patients with severe asthma requires rationalizing a personalized approach to treatment to account for the potential risks of adverse events. Information on the development of drug-induced sarcoid-like syndrome during anti-IL-4, -13 therapy is limited to isolated publications and requires a detailed analysis of each specific clinical case. This is necessary to further develop a patient profile associated with higher risks of adverse events related to anti-IL-4, -13 therapy, as well as to develop a rational algorithm for dynamic laboratory and instrumental monitoring and to define its timing.

The aim was to investigate the emergence of drug-induced sarcoid-like syndrome associated with anti-IL-4, -13 treatment in a patient with severe asthma and chronic rhinosinusitis with nasal polyps (CRSwNP), as well as to evaluate the safety and efficacy profile of alternative biological therapies.

Conclusion. The therapeutic potential of anti-IL-4, -13 therapy in patients with bronchial asthma and CRSwNP is undisputed. Given the risk of adverse events associated with biological therapy, strict frequent monitoring of laboratory and instrumental data is required. Further investigation of the efficacy and safety of biological therapy in asthma and CRSwNP will help determine the optimal timing of treatment response and monitoring intervals, identify possible predictors of adverse events, and develop personalized therapeutic approaches.

About the Authors

N. A. Kuleshova
State Budgetary Healthcare Moscow City Institution “Moscow Clinical Research Center Hospital 52, Moscow Department of Healthcare”
Russian Federation

Natavan A. Kuleshova, Pulmonologist, Pulmonology Department

ul. Pekhotnaya 3, Moscow, 123182


O. A. Mukhina
State Budgetary Healthcare Moscow City Institution “Moscow Clinical Research Center Hospital 52, Moscow Department of Healthcare”; State Budgetary Moscow City Institution “Research Institute for Healthcare Organization and Medical Management, Moscow Department of Healthcare”
Russian Federation

Olga A. Mukhina, Allergist-Immunologist, Consultative and Diagnostic Department of Allergology and Immunology, Moscow City Scientific and Practical Center of Allergology and Immunology, State Budgetary Healthcare Moscow City Institution “Moscow Clinical Research Center Hospital 52, Moscow Department of Healthcare”; Leading Specialist, Organizational and Methodological Department for Allergology-Immunology and Pulmonology, State Budgetary Moscow City Institution “Research Institute for Healthcare Organization and Medical Management, Moscow Department of Healthcare”

ul. Pekhotnaya 3, Moscow, 123182,

ul. Bolshaya Tatarskaya 30, Moscow, 115184


E. N. Bobrikova
State Budgetary Healthcare Moscow City Institution “Moscow Clinical Research Center Hospital 52, Moscow Department of Healthcare”
Russian Federation

Elena N. Bobrikova, Allergist-Immunologist, Head of the Consultative and Diagnostic Department of Allergology and Immunology, Moscow City Scientific and Practical Center of Allergology and Immunology

ul. Pekhotnaya 3, Moscow, 123182


I. P. Beloglazova
State Budgetary Healthcare Moscow City Institution “Moscow Clinical Research Center Hospital 52, Moscow Department of Healthcare”
Russian Federation

Irina P. Beloglazova, Candidate of Medicine, Head of the Pulmonology Department

ul. Pekhotnaya 3, Moscow, 123182


T. S. Kruglova
State Budgetary Healthcare Moscow City Institution “Moscow Clinical Research Center Hospital 52, Moscow Department of Healthcare”
Russian Federation

Tatyana S. Kruglova, Candidate of Medicine, Head of the Department of Allergology-Immunology, Moscow City Scientific and Practical Center of Allergology and Immunology

ul. Pekhotnaya 3, Moscow, 123182


V. V. Parshin
State Budgetary Healthcare Moscow City Institution “Moscow Clinical Research Center Hospital 52, Moscow Department of Healthcare”
Russian Federation

Vasilii V.Parshin, Head of the Radiology Department

ul. Pekhotnaya 3, Moscow, 123182


Yu. P. Moiseeva
Federal State Budgetary Educational Institution of Additional Professional Education “Russian Medical Academy of Continuous Professional Education”, Ministry of Health of Russia; Federal Budgetary Institution “Central Clinical Hospital of Civil Aviation”
Russian Federation

Yuliya P. Moiseeva, Candidate of Medicine, Assistant, Department of Otorhinolaryngology, Federal State Budgetary Educational Institution of Additional Professional Education “Russian Medical Academy of Continuous Professional Education”, Ministry of Health of Russia; Otorhinolaryngologist, Federal Budgetary Institution “Central Clinical Hospital of Civil Aviation”

ul. Barrikadnaya 2/1, Moscow, 123995, 

Ivan’kovskoye shosse 7, Moscow, 125367


A. V. Karaulov
Federal State Autonomous Educational Institution of Higher Education I.M.Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University)
Russian Federation

Alexander V. Karaulov, Doctor of Medicine, Professor, Academician of the Russian Academy of Sciences, Head of the Department of Clinical Immunology and Allergology, Head of the Laboratory of Immunopathology

ul. Trubetskaya 8, build. 2, Moscow, 119991


M. A. Lysenko
State Budgetary Healthcare Moscow City Institution “Moscow Clinical Research Center Hospital 52, Moscow Department of Healthcare”; Federal State Autonomous Educational Institution of Higher Education “N.I.Pirogov Russian National Research Medical University” of the Ministry of Health of the Russian Federation
Russian Federation

Maryana A. Lysenko, Doctor of Medicine, Professor, Director, State Budgetary Healthcare Moscow City Institution “Moscow Clinical Research Center Hospital 52, Moscow Department of Healthcare”; Professor, Department of General Therapy, Institute of Continuous Education and Professional Development, Federal State Autonomous Educational Institution of Higher Education “N.I.Pirogov Russian National Research Medical University” of the Ministry of Health of the Russian Federation

ul. Pekhotnaya 3, Moscow, 123182,

ul. Ostrovityanova 1, Moscow, 117997


A. A. Vizel
Federal State Budgetary Educational Institution of Higher Education “Kazan State Medical University” of the Ministry of Health of the Russian Federation
Russian Federation

Aleksandr A. Vizel, Doctor of Medicine, Professor, Head of Department of Phthisiology and Pulmonology

ul. Butlerova 49, Kazan, 420012, Republic of Tatarstan


D. S. Fomina
State Budgetary Healthcare Moscow City Institution “Moscow Clinical Research Center Hospital 52, Moscow Department of Healthcare”; Federal State Autonomous Educational Institution of Higher Education I.M.Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University); Non-profit Joint Stock Company “Astana Medical University”, Ministry of Health of the Republic of Kazakhstan
Russian Federation

Darya S. Fomina, Doctor of Medicine, Professor, Head of the Moscow City Scientific and Practical Center of Allergology and Immunology, State Budgetary Healthcare Moscow City Institution “Moscow Clinical Research Center Hospital 52, Moscow Department of Healthcare”; Professor, Department of Clinical Immunology and Allergology, Head of the Laboratory of Immunopathology, Federal State Autonomous Educational Institution of Higher Education I.M.Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University); Professor, Non-profit Joint Stock Company “Astana Medical University”, Ministry of Health of the Republic of Kazakhstan; Chief Freelance Allergist-Immunologist, Moscow City Healthcare Department

ul. Pekhotnaya 3, Moscow, 123182,

ul. Trubetskaya 8, build. 2, Moscow, 119991,

ul. Beibitshilik 49a, Astana, 010000, Republic of Kazakhstan


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Review

For citations:

Kuleshova N.A., Mukhina O.A., Bobrikova E.N., Beloglazova I.P., Kruglova T.S., Parshin V.V., Moiseeva Yu.P., Karaulov A.V., Lysenko M.A., Vizel A.A., Fomina D.S. Drug-induced sarcoidosis-like syndrome associated with anti-IL-4, -13 inhibitor therapy in a patient with T2-associated comorbidities: clinical case. PULMONOLOGIYA. 2026;36(3):522-531. (In Russ.) https://doi.org/10.18093/0869-0189-2026-36-3-522-531

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ISSN 0869-0189 (Print)
ISSN 2541-9617 (Online)

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