Lung transplantation in a patient with α1-antitrypsin deficiency emphysema
N. A. Karchevskaya,
M. S. Kevorkova,
E. А. Tarabrin,
T. Е. Kallagov,
I. U. Ibavov,
E. I. Pervakova,
A. L. Cherniaev,
M. V. Samsonova,
M. Sh. Khubutiya,
A. G. Chuchalin https://doi.org/10.18093/0869-0189-2022-32-6-899-905
Abstract
The condition of patients with chronic lung diseases is gradually deteriorating despite modern drug therapy and often progresses to severe respiratory failure. Thus, it is important to consider other options, including surgical methods, to help such patients. The aim of the study is to demonstrate potential additional pharmacological and surgical treatment algorithms for chronic obstructive pulmonary disease (COPD) associated with α1-anti-trypsin (A1AT) deficiency. Results. The analysis of long-term medical history (from the onset to the terminal stage of the respiratory failure) of a patient with A1AT deficiency was performed. Conclusion. Patients with COPD associated with A1AT deficiency require combination inhaled controller therapy and augmentation therapy with a1-proteinase inhibitor. Patients with terminal stage of the disease need lung transplantation unless they have any contraindications.
About the Authors
N. A. Karchevskaya
N.V. Sklifosovskiy State Research Institute of Emergency Care, Moscow Healthcare Department; Federal Pulmonology Research Institute, Federal Medical and Biological Agency of Russia
Russian Federation
Competing Interests:
Russian Federation
Natalia A. Karchevskaya - Pulmonologist, Researcher, Department of Thoracoabdominal Surgery, N.V. Sklifosovskiy State Research Institute of Emergency Care, Moscow Healthcare Department; Researcher, Federal Pulmonology Research Institute, Federal Medical and Biological Agency of Russia.
Bolshaya Sukharevskaya pl. 3, Moscow, 129090; Orekhovyy bul'var 28, Moscow, 115682
tel.: (926) 432-47-44
Competing Interests:
The authors declare absence of conflict of interests
M. S. Kevorkova
Pirogov Russian National Research Medical University (Pirogov Medical University), Healthcare Ministry of Russia
Russian Federation
Competing Interests:
Russian Federation
Marina S. Kevorkova - Assistant, Department of Hospital Internal Medicine, Pediatric Faculty, Pirogov Russian National Research Medical University (Pirogov Medical University), Healthcare Ministry of Russia.
Ostrovityanova ul. 1, Moscow, 117997
tel.: (964) 704-71-17
Competing Interests:
The authors declare absence of conflict of interests
E. А. Tarabrin
N.V. Sklifosovskiy State Research Institute of Emergency Care, Moscow Healthcare Department; I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University)
Russian Federation
Competing Interests:
Russian Federation
Evgeniy А. Tarabrin - Doctor of Medicine, Chief Researcher, Department of Emergency Thoracoabdominal Surgery, N.V. Sklifosovskiy State Research Institute of Emergency Care, Moscow Healthcare Department; Head of the Department of Hospital Surgery No.2, Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University).
Bolshaya Sukharevskaya pl. 3, Moscow, 129090; Trubetskaya ul. 8, build. 2, Moscow, 119991
tel.: (916) 268-23-48
Competing Interests:
The authors declare absence of conflict of interests
T. Е. Kallagov
N.V. Sklifosovskiy State Research Institute of Emergency Care, Moscow Healthcare Department; I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University)
Russian Federation
Competing Interests:
Russian Federation
Taimuraz Е. Kallagov - Researcher, Department of Emergency Thoracoabdominal Surgery, N.V. Sklifosovskiy State Research Institute of Emergency Care, Moscow Healthcare Department; Head of the Thoracic Surgery Department, University Clinical Hospital No.4, Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University).
Bolshaya Sukharevskaya pl. 3, Moscow, 129090; Trubetskaya ul. 8, build. 2, Moscow, 119991
tel.: (965) 336-65-42
SPIN: 6358-5525, Author ID: 960789
Competing Interests:
The authors declare absence of conflict of interests
I. U. Ibavov
N.V. Sklifosovskiy State Research Institute of Emergency Care, Moscow Healthcare Department
Russian Federation
Competing Interests:
Russian Federation
Ibragim U. Ibavov - Thoracic Surgeon, Researcher, Department of Emergency Thoracoabdominal Surgery, N.V. Sklifosovskiy State Research Institute of Emergency Care, Moscow Healthcare Department.
Bolshaya Sukharevskaya pl. 3, Moscow, 129090
tel.: (926) 572-84-21
Competing Interests:
The authors declare absence of conflict of interests
E. I. Pervakova
N.V. Sklifosovskiy State Research Institute of Emergency Care, Moscow Healthcare Department
Russian Federation
Competing Interests:
Russian Federation
Elza I. Pervakova - Candidate of Medicine, Head of the Resuscitation аnd Intensive Care Unit with Dialysis Methods for Patients after Organ Transplantation, N.V. Sklifosovskiy State Research Institute of Emergency Care, Moscow Healthcare Department.
Bolshaya Sukharevskaya pl. 3, Moscow, 129090
tel.: (915) 087-71-52
Competing Interests:
The authors declare absence of conflict of interests
A. L. Cherniaev
Pirogov Russian National Research Medical University (Pirogov Medical University), Healthcare Ministry of Russia; Federal Pulmonology Research Institute, Federal Medical and Biological Agency of Russia; A.P. Avtsyn Research Institute of Human Morphology
Russian Federation
Competing Interests:
Russian Federation
Andrey L. Cherniaev - Doctor of Medicine, Professor; Professor, Department of Pathological Anatomy and Clinical Pathological Anatomy, Faculty of Medicine, Pirogov Russian National Research Medical University (Pirogov Medical University), Healthcare Ministry of Russia, Head of the Department of Fundamental Pulmonology, Federal Pulmonology Research Institute, Federal Medical and Biological Agency of Russia, Leading Researcher, Laboratory of Clinical Morphology, Avtsyn Research Institute оf Human Morphology оf Petrovsky National Research Centre оf Surgery.
Ostrovityanova ul. 1, Moscow, 117997; Orekhovyy bul'var 28, Moscow, 115682; Tsyurupy ul. 3, Moscow, 117418
tel.: (495) 465-58-59
Competing Interests:
The authors declare absence of conflict of interests
M. V. Samsonova
Federal Pulmonology Research Institute, Federal Medical and Biological Agency of Russia; A.S. Loginov Moscow State Clinical and Research Center, Moscow Healthcare Department
Russian Federation
Competing Interests:
Russian Federation
Maria V. Samsonova - Doctor of Medicine, Head of Laboratory of Pathological Anatomy and Immunology, Federal Pulmonology Research Institute, Federal Medical and Biological Agency of Russia, Senior Researcher, Laboratory of Pathomorphology, A.S. Loginov Moscow State Clinical and Research Center, Moscow Healthcare Department.
Orekhovyy bul'var 28, Moscow, 115682; Shosse Entuziastov 86, Moscow, 111123
tel.: (495) 465-58-59
Competing Interests:
The authors declare absence of conflict of interests
M. Sh. Khubutiya
N.V. Sklifosovskiy State Research Institute of Emergency Care, Moscow Healthcare Department; A.I. Yevdokimov Moscow State University of Medicine and Dentistry of the Ministry of Healthcare of the Russian Federation
Russian Federation
Competing Interests:
Russian Federation
Mogeli Sh. Khubutiya - Doctor of Medicine, Professor, Academician of Russian Academy of Science, President, N.V. Sklifosovskiy State Research Institute of Emergency Care, Moscow Healthcare Department, Head of the Department of Transplantology and Artificial Organs, A.I. Yevdokimov Moscow State University of Medicine and Dentistry of the Ministry of Healthcare of the Russian Federation.
Bolshaya Sukharevskaya pl. 3, Moscow, 129090; Delegatskaya ul. 20, build. 1, Moscow, 127473
tel.: (495) 628-47-57
Competing Interests:
The authors declare absence of conflict of interests
A. G. Chuchalin
Pirogov Russian National Research Medical University (Pirogov Medical University), Healthcare Ministry of Russia
Russian Federation
Competing Interests:
Russian Federation
Alexander G. Chuchalin - Doctor of Medicine, Professor, Academician of Russian Academy of Sciences, Head of Department of Hospital Internal Medicine, Pediatric Faculty, Pirogov Russian National Research Medical University (Pirogov Medical University), Healthcare Ministry of Russia; Chairman of the Executive Board of Russian Respiratory Society.
Ostrovityanova ul. 1, Moscow, 117997
tel.: (499) 780-08-50
SPIN: 7742-2054
Competing Interests:
The authors declare absence of conflict of interests
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For citations:
Karchevskaya N.A., Kevorkova M.S., Tarabrin E.А., Kallagov T.Е., Ibavov I.U., Pervakova E.I., Cherniaev A.L., Samsonova M.V., Khubutiya M.Sh., Chuchalin A.G. Lung transplantation in a patient with α1-antitrypsin deficiency emphysema. PULMONOLOGIYA. 2022;32(6):899-905. (In Russ.) https://doi.org/10.18093/0869-0189-2022-32-6-899-905
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