Immunomorphological characteristic of lung cancer basal membranes
Abstract
49 lung cancer cases with different histologic forms were investigated. The study was performed with the help of cryosta-tic slices with minimal number of artifacts, induced by disguise and destruction of tissue antigens during their histological work-up. The distribution and correlation between the main structural components of basal membranes (BM) — type 4 collagen, laminin and heparansulfateproteoglycane — were studied. It was established that these markers take part in the forming of lung cancer BM. Exept for carcinoid tumors and zones of desmoplasia, the dissociation of markers bears microstructural character. The type 4 collagen, laminin and heparansulfateproteoglycane to a greater extend are elicited in desmoplasia zones and intercellular matrix. The degree of lung cancer BM expression does not depend on the histological form and the level of tissue differentiation of the tumor. That investigation testifies about the different variants of tumor invasion, regardless of its histologic form, the level of differentiation and localization in central or peripheral parts of the lung.
About the Authors
G. A. Frank
Московский научно-исследовательский онкологический институт им. П.А. Герцена
Russian Federation
Russian Federation
L. V. Lytvinova
Московский научно-исследовательский онкологический институт им. П.А. Герцена
Russian Federation
Russian Federation
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Review
For citations:
Frank G.A., Lytvinova L.V. Immunomorphological characteristic of lung cancer basal membranes. PULMONOLOGIYA. 1992;(2):34-49. (In Russ.)
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