Clinical immunological aspects of lipine use in patients with nonspecific lung diseases

Abstract

87 patients with nonspecific lung disease (NLD ) complicated with respiratory distress syndrome were medicated with complex treatment in com bination with Lipin (the com pound of phospholipids). All patients were investigated by routine clinical, complex functional and immunological tests including ventilatory and oxygen-transport function of the lung, acid-base balance and blood gases, T- and В-systems of lymphocytes, T-cell subpopulation content, the level of autoimmune processes and nonspecific resistance. It was found that Lipin had positive influence on alveolar ventilation, improved oxygen perfusion through the airohematological membrane, decreased arterial hypoxemia, economized ventilatory function. The mechanism of the action is based on the surfactant system normalizing in lungs which had been disturbed by pulmonary disorders. Lipin had the normalizing influence on immune status owing to the oxygen regimen improvement. This influence was strongly pronounced on peripheral phagocytes and T-lymphocytes. Moreover, the positive dynamics has been obtained rather quickly.