Levels of cyclic 3’5’-adenosine monophosphate of lymphocytes and immunological status conditions during dynamics of various pneumonia cources

Abstract

As a result of executed studies of the functional activity of the adenylate cyclase system (ACS) of periferal lymphocites and the immunological status condition in patients with various cources of pneumonia, the stagiality of changes of basal intracellular c-AMP levels (pmoll/106 cells), the beta-2-adrenoreception activity, and lymphocitarial response to concavaline A was revealed.

The activity decrease of ACS at the beginning of pneumonia was correlated with the diminishing of such parameters as E-ROC, Ea-ROC, EAC-ROC, C3 complement fraction and with changes of levels of IgA, M, G, that is more expressed in patients with severe forms of the disease.

The tendency to the activity repairment of ACS after 7—10 days of hospital treatment was noted in patients with uncomplecated entities of pneumonia accompanied by immunological status normalization. The tendency to the adenylate cyclase activity repairment was noted also in patients cured with hyperimmune antistaphylococcus serum, that was not signed in patients with the complicated disease cured with traditional treatment only.

Afetr 21 days, in the group of patients with uncomplicated pneumonia cured with sustitutional immunological correction, the ACS activity coincided with immunological and clinical normalization of parameters. Firmy impairments of immunological parameters and the severity of clinical manifestation of the disease were accompanied by tyhe absence of similar c-AMP dynamics in patients with complicated pneumonia entities not cured with immunocorrection methods.

The dynamics of the lymphocite ASC activity of patients with various pneumonia forms demonstrates the process of clinical immunological changes and points to the positive influence of the proper usage of immunocorrection treatment on molecular mechanisms of immunity regulation during the mentioned disease.