The effect of troventol on free radical processes

Abstract

The medication effect on oxidative metabolism of various phagocyte types was studied by the luminol dependant chemiluminescent (ChL) method for investigating the troventol action mechanism. Peroxide lipid oxidation (PLO) in liver, lung, and brain homogenates was investigated to com pare the effects of atropine and atrovent.
It was found that troventol inhibited the ChL-response of alveolar macrophages (AM) in 50—60% in comparison with placebo. That effect is considered to be explained by its influence on generation mechanism s of reactive oxygen species (ROS) by certain cells. Moreover, troventol did not influenced on activation of peritoneal macrophages.
As well the generation inhibition of ROS by AM with troventol as the effect absence in peritoneal macrophages are considered to be depended on features of reception interaction with phagocytes.
It was shown by the model system of lipid autooxidation in the brain homogenate that troventol has a great antioxidant activity. Nevertheless, it was not found any essential inhibition of PLO processes by the drug during the PLO induction with ferrous ions in lung and liver homogenates.
It was suggested that the inhibition may be conditioned by the various lipid content and the antioxidant delivery of various tissues as well as by microsomal function of the detoxitizing system w here this drug like the other xenobiotics is hydroxilized.