Free ferrous ions intact rat tissues and their accumulation during experimental hemochromatosis. The electron paramagnetic resonance study
Abstract
The possibility of intracellular free iron registration by the electron paramagnetic resonance method with' desferal use as iron chelator was demonstrated in the study. The essential increase of desferal available iron was found in liver, kidney, and spleen during experimental hemochromatosis. Heart, lungs, and brain were more resistant to free iron accumulation.
About the Authors
A. V. KozlovRussian Federation
A. Tomasi
Italy
A. Masini
Italy
Y. A. Vladimiro
Russian Federation
References
1. Ванин А.Ф. / / Биохимия.— 1967.— Т.32.— С.277—282.
2. Козлов А.В., Егоров Д.Ю ., Владимиров Ю.А. и др. / / Жури, физ. химиии.— 1990.— Т.64.— С.225—227.
3. Bacon B .R ., Tavill A.S., Brittenham G.M. et al. / / J. Clin. Invest.— 1983.— Vol.71.— P.429—439.
4. Bacon B.R.O., N eill R. / / Hepatology.— 1985.— Vol.5.— Abstr. 13.
5. Bacon B.R., Healey J.F., Brittenham G.M. et al. / / Gastroenterology.— 1986.— Vol.90.— P. 1844— 1853.
6. Bacon B.R., Britton R.S., O’Neill R. / / Hepatology.— 1989.— Vol.9.— P.398—404.
7. Ceccarelli D., Predieri G., Muscatello U. et al. / / Biochem. Biophys. Res. Commun.— 1991.— Vol.176.— P.1262— 1268.
8. Figueiredo M .S., Baffa 0 ., Neto J.B. et al. / / Res. Exp. Med.— 1993.— Vol. 193.— P.27—37.
9. Galleano M ., Puntarulo S. / / Toxicology.— 1992.— Vol.76.— P.27—38.
10. Iancu T.C., Shiloh H., Link G. et al. / / Br. J. Exp. Pathol.— 1987.— Vol.68.— P.53—65.
11. Kozlov A.V., Yegorov D.Yu., Vladimirov Yu. A. et al. / / Free Radical Biol. Med.— 1992.— Vol. 13.— P.9— 14.
12. Masini A., Trenti T., Ventura E. et al. / / Biochem. Biophys. Res. Commun.— 1984.— Vol. 124.— P.462—469.
13. Vanin A.F., Osipov A.N., Kubrina L. N. et al. / / Stud. Biophys.— 1975.— Vol.49.— P.13—25.
14. Yegorov D. Y., Kozlov A.V., A zizova O.A. et al. / / Free Radical Biol. Med.— 1993.— Vol. 15.— P.565—574.
Review
For citations:
Kozlov A.V., Tomasi A., Masini A., Vladimiro Y.A. Free ferrous ions intact rat tissues and their accumulation during experimental hemochromatosis. The electron paramagnetic resonance study. PULMONOLOGIYA. 1995;(1):53-56. (In Russ.)