Role of free ferrum in peroxide lipid oxidation processes during asbestos influence
Abstract
The ferrous ion content in blood serum and free liver ferrum and their interaction with changes of peroxide lipid oxidation (PLO) processes in hepatic and pulmonary tissue were studied during various periods of chrysotil—asbestos influence. The effect of natural rhutinum flavonoid from P-vitamin on these parameters was also investigated.
The free ferrum pool state was studied by EPR-spectroscopy with nitrozil g-factor complex (2.03) formation evaluation.
After a month, the significant increase of oxyprolin in the pulmonary tissue was found after a single intratracheal injection of 50mg of powder. The enforcement of peroxidation processes in hepatic and pulmonary tissues was also found (at 1.4 and 1.7 times respectively). The total ferrum content in blood serum corresponded to the control value. Moreover, the transferrin content was decreased at 1.3 times, that testify about the ferric content decrease in blood serum. The free ferrum content was also low in hepatic tissue. The single rhutinum instillation did not influence on the dust toxic action.
After 6 months since powder inhalation, the enforcement of PLO processes in hepatic and pulmonary tissues was discovered (at 2.8 and 1.5 times respectively). The ferrum content was higher in 20%, that can be explained by its extraction from ferritin. The studied flavonoid showed the expressed antiasbestos action after three month therapy only.
About the Authors
S. K. Sohodaeva
НИИ пульмонологии М3 и МП РФ
Russian Federation
Russian Federation
Е. А. Ostrcikhovich
НИИ пульмонологии М3 и МП РФ
Russian Federation
Russian Federation
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Review
For citations:
Sohodaeva S.K., Ostrcikhovich Е.А. Role of free ferrum in peroxide lipid oxidation processes during asbestos influence. PULMONOLOGIYA. 1995;(1):50-52. (In Russ.)
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