Leukocytal hemiluminescence param eters in bronchial asthma infants obtaining hypercapnic hypoxic mixture inhalation

Abstract

The CO₂ effect on phagocytal generation of reactive oxygen species was studied in 40 bronchial asthma infants obtaining therapy with hypercapnic hypoxic gas mixture (HHGM) inhalations. It was found that chemiluminescence intensity parameters were greater in that patients during the postattack period than in healthy infants. During the intermedia period, the parameters decreased but were significantly higher than in controls. The satisfactory leucocyte sensitivity to CO₂ was found in 37.5% of patients, that well correlates with positive clinical effect. The lower effect from HHGM was noted in 62.5% of infants with the decreased reaction to CO₂. The role of leukocytes in bronchoconstriction was shown.