Plateletaferesis in complex therapy in patients with various asthma forms
Abstract
Basing on the active role of platelets (Pt’s) in bronchial asthma (BA) pathogenesis, the influence of plateletapheresis (PtA) on bronchial asthma and Pt’s functional activity was investigated. PtA was used in 88 patients with various asthma forms. 41 patients with atopic BA, 28 patients with “mixed” asthma, and 19 ones with aspirin BA were treated. The clinical state and the Pt’s functional parameters (aggregation, intracellular Ca2+, Pt’s secretion, levels of Pt’s-binding IgE) were evaluated. The therapy was efficient in 86% of patients with atopic BA, in 62% of ones with aspirin-sensitive BA, in 46% of patients with “mixed” BA. The results of the study demonstrated that PtA restores normal platelet functional status parameters, especially in atopic patients with dramatic clinical course of the disease.
About the Authors
A. R. Tatarskiy
НИИ пульмонологии МЗ РФ
Russian Federation
Russian Federation
A. S. Emirova
НИИ пульмонологии МЗ РФ
Russian Federation
Russian Federation
E. V. Bobkov
НИИ пульмонологии МЗ РФ
Russian Federation
Russian Federation
K. M. Alieva
НИИ пульмонологии МЗ РФ
Russian Federation
Russian Federation
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Review
For citations:
Tatarskiy A.R., Emirova A.S., Bobkov E.V., Alieva K.M. Plateletaferesis in complex therapy in patients with various asthma forms. PULMONOLOGIYA. 1994;(4):58-63. (In Russ.)
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