The specific immunotherapy of pollinosis with a new russian conjugated allergen

Abstract

A comparative clinical and immunological study of specific immunotherapy with three allergens in comparison with placebo was performed in 60 patients with pollinosis sensitized to timothy grass (Phleum pratense) pollen. These allergens were: the commercial timothy pollen allergen, the purified timothy pollen allergen (PTPA), and purified timothy pollen allergen conjugated with polyoxidonium (PTPA-PO). The specific immunotherapy with PTPA-PO demonstrated the higher clinical efficacy, the lack of systemic reactions, the significant decrease of skin and nasal sensitivity to specific allergen and histamine, and increased specific IgG antibodies production.