The functional state of rens in patients with suppurative pulmonary disease

Abstract

104 patients with suppurative pulmonary diseases (SPD) were examined to study the functional state of rens for correction of traditional therapy. 32 healthy subject were as a control group. Glomerular filtration was evaluated with the endogenous creatinine clearance; clearances of concentration, osmotic active substations, and osmotic free water were calculated. Central hemodynamics was evaluated. Gammascintiography was carried out to estimate renal microcirculation.

Acute SPD (ASPD) were presented by pulmonary abscess, abscessed pneumonia, pleural empiema and staphylococcic pulmonary destruction. Chronic ones (CSPD) were presented by bronchiectasia and chronic purulent bronchitis. During ASPD, the increase of renal excretion of titred acids and total excretion of hydroions were revealed; during CSPD, these changes were more moderate. The scintigraphic data showed the significant impairment of renal microcirculation.

The results of the study showed that in patients with severe SPD the revealed impairments directed to the tubulointerstitial nephropathy formation. Dystrophy of tubular epithelium, focal sclerosis and lymphohystiocytic infiltration of interstition were found. Use of intravessel laser radiation in complex with traditional therapy promoted the normalization of osmotic homeostasis and the increase of the clearance of midle molecular size peptides.