Clinical diagnostical benefit of acid fat content investigation in endobronchial fluids in patients with lung cancer
Abstract
The comparative estimation of lipid content changes in tracheobrocnhial secretion in patients with malignant tumor and non-specific pulmonary diseases was carried out. The percent ratio of lipid acids content in lipid extracts of endobronchial lavage fluids was studied by the gase-fluid chromatography method. 20 patients with non-specific pulmonary diseases and 52 patients with verified pulmonary oncopathology were examined. It was found, that during malignant tumor, the percent content of stearinic and oleinic acids is significantly greater than in non-specific pulmonary diseases. Duirng lung cancer, the arachidonic acid content is significantly lower in comparison with non-specific pulmonary diseases and control values. The diagnostical coefficient was calculated: the content of stearinic acid in pescents plus the oleinic acid content in percents and all that is divided on the arachidonic acid content in percents. During that index increase in bronchial lavage lipid extract more than 8.5 r.u., the diagnosis of malignant pulmonary tumor may be established.
About the Authors
V. M. Provotorov
Воронежский государственный медицинский институт имени Н.Н.Бурденко
Russian Federation
Russian Federation
V. I. Buzurtanov
Воронежский государственный медицинский институт имени Н.Н.Бурденко
Russian Federation
Russian Federation
References
1. Денисов Л.Е., Прохорович А.Л., Верткин А.Л. и др. Жирные кислоты и злокачественные опухоли / / Клин. мед.— 1992.— № 7— 8.— С.20—23.
2. Коган Е.А. Предрак и рак легкого / / Арх. пат.— 1990.— № 6.— С.76— 83.
3. Лукомский Г.И., Шулутко М.Л., Виннер М.Г., Овчинников A.A. Бронхопульмонология.— М., 1982.— С.400.
4. Синяк K.M., Оргель М.Я., Крук В.И. Метод приготовления липидов крови для газохроматографического исследования / / Лаб. дело.— 1976.— № 1.— С.37—41.
5. Трахтенберг А.Х. Рак легкого.— М., 1987.— С.304.
6. Томпсон Г.Р. Руководство по гиперлипидемии: Пер. с англ.— М., 1990.— С.380.
7. Borgeson C.E., Pardini L., Pardini R.S., Reitz R.C. Effects of Dietary fish oil on human mammary carcinoma on lipid metabolizing enzymes / / Lipids.— 1989.— Vol.24, № 4.— P.290—295.
8. Das V.N., Begin M.E., Ells G. et al. Polyunsaturated fatty acid augment free radical ceneration in tumor cells in vitro / / Biochem. Biophys. Res. Commun.— 1987.— Vol. 145, № 1.— P. 15—24.
9. Habib N.A., Hershman M.I., Smadija C. et al. Desaturation of cell membrane fatty by urine from patients with cancer / / Surg. Res. Commun.— 1987.— № 1.— P.111.
10. Lawson N., Taylor A. Y., Manche A. et al. Inadequacy of oleic acid in erithrocites as a marker of malignancies / / Br. Med.J.— 1987.— Vol.294.— P.769.
11. Neoptolemos J.P., Clauton H., Heagerty A.M. et al. Dietary fat in relation to fatty acid composition of red cells and adipose tissue in colorectal cancer / / Br. J. Cancer.— 1989.— Vol.58, № 5.— P.575—579.
12. Salmong C.E., Beaglenole R., Prior I.A. Are low cholesterol values associated with excess mortality / / Br. Med. J.— 1985.— Vol.290.— P.422—424.
13. Wood C.B., Habib N.A., Thompson A. et al. Increase of oleic acid in erythrocites associated with malignancies / / Br. Med. Med. J.— 1958.— Vol.291.— P.163— 164.
Review
For citations:
Provotorov V.M., Buzurtanov V.I. Clinical diagnostical benefit of acid fat content investigation in endobronchial fluids in patients with lung cancer. PULMONOLOGIYA. 1995;(3):31-36. (In Russ.)
Views:
81
Email this article 